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NEDD8 antibody (N-Term)
NEDD8
Reactivity: Human
WB, IHC (p)
Host: Rabbit
Polyclonal
RB0639
unconjugated
Product Details anti-NEDD8 Antibody
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Target
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NEDD8
(Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8))
Binding Specificity
All epitopes for NEDD8 antibodies
AA 1-32, N-Term
Reactivity
All reactivities for NEDD8 antibodies
Human
Host
All hosts for NEDD8 antibodies
Rabbit
Clonality
All clonalities for NEDD8 antibodies
Polyclonal
Conjugate
All conjugates for NEDD8 antibodies
This NEDD8 antibody is un-conjugated
Application
All applications for NEDD8 antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Predicted Reactivity
B, M, Rb, Rat
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This NEDD8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-32 amino acids from the N-terminal region of human NEDD8.
Clone
RB0639
Isotype
Ig Fraction
Top Product
Discover our top product NEDD8 Primary Antibody
Alternatives
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anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) (N-Term) antibody
NEDD8
Reactivity: Human, Mouse, Rat, Monkey, Cow, Xenopus laevis
WB, IHC, IHC (p), IF, FACS, IP
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
WB: 1:1000. IHC-P: 1:50~100
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date
6 months
Target Details for NEDD8
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Target
NEDD8
(Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8))
Alternative Name
NEDD8 (NEDD8 Products )
Synonyms
NEDD-8 antibody, Rub1 antibody, CG10679 antibody, Dmel\\CG10679 antibody, NEDD8 antibody, dNEDD8 antibody, nedd8 antibody, ubiquitin antibody, si:zc14a17.5 antibody, GB17785 antibody, DDBDRAFT_0218116 antibody, DDBDRAFT_0238041 antibody, DDB_0218116 antibody, DDB_0238041 antibody, nedd8.S antibody, neural precursor cell expressed, developmentally down-regulated 8 antibody, neural precursor cell expressed, developmentally down-regulated gene 8 antibody, CG10679 gene product from transcript CG10679-RB antibody, Nedd8 antibody, ubiquitin-like protein Nedd8 antibody, neural precursor cell expressed, developmentally down-regulated 8 L homeolog antibody, NEDD8 antibody, Nedd8 antibody, nedd8 antibody, nedd8.L antibody
Background
NEDD8 is a ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
Molecular Weight
9072
Gene ID
4738
NCBI Accession
NP_006147
UniProt
Q15843
Pathways
Ubiquitin Proteasome Pathway
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