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MEK1 antibody (pSer222)
MAP2K1
Reactivity: Human
WB, DB
Host: Rabbit
Polyclonal
RB15989
unconjugated
Product Details anti-MEK1 Antibody
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Target
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MEK1 (MAP2K1)
(Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
Binding Specificity
All epitopes for MEK1 antibodies
pSer222
Reactivity
All reactivities for MEK1 antibodies
Human
Host
All hosts for MEK1 antibodies
Rabbit
Clonality
All clonalities for MEK1 antibodies
Polyclonal
Conjugate
All conjugates for MEK1 antibodies
This MEK1 antibody is un-conjugated
Application
All applications for MEK1 antibodies
Western Blotting (WB), Dot Blot (DB)
Predicted Reactivity
D, Ha, M, Rb, Rat, X, C
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This MEK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S222 of human MEK1.
Clone
RB15989
Isotype
Ig Fraction
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Alternatives
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Application Details
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Application Notes
WB: 1:500. DB: 1:500
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date
6 months
Target Details for MEK1
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Target
MEK1 (MAP2K1)
(Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
Alternative Name
MEK1 (MAP2K1 Products )
Synonyms
Mek1 antibody, CFC3 antibody, MAPKK1 antibody, MEK1 antibody, MKK1 antibody, PRKMK1 antibody, MEKK1 antibody, Prkmk1 antibody, mek-2 antibody, si:ch211-242m18.2 antibody, wu:fj56a12 antibody, wu:fj61b01 antibody, zgc:56557 antibody, ATMEK1 antibody, F20B18.180 antibody, F20B18_180 antibody, MAP kinase/ ERK kinase 1 antibody, MITOGEN ACTIVATED PROTEIN KINASE KINASE antibody, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 antibody, NMAPKK antibody, MEK antibody, mitogen activated protein kinase kinase 1 antibody, mitogen-activated protein kinase kinase 1 antibody, mitogen-activated protein kinase kinase 1 L homeolog antibody, MAP kinase/ ERK kinase 1 antibody, Map2k1 antibody, MAP2K1 antibody, map2k1.L antibody, map2k1 antibody, MEK1 antibody
Background
MEK1is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.
Molecular Weight
43439
Gene ID
5604
NCBI Accession
NP_002746
UniProt
Q02750
Pathways
MAPK Signaling , RTK Signaling , Interferon-gamma Pathway , Fc-epsilon Receptor Signaling Pathway , Neurotrophin Signaling Pathway , Activation of Innate immune Response , Toll-Like Receptors Cascades , Autophagy , Signaling of Hepatocyte Growth Factor Receptor , BCR Signaling
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