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Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 199-235), (C-Term) antibody

Details for Product No. ABIN390286, Supplier: Log in to see
Antigen
  • hadh2
  • im:6899159
  • wu:fj61f03
  • zgc:101605
  • abad
  • camr
  • erab
  • hcd2
  • hsd10
  • mhbd
  • mrpp2
  • mrx17
  • mrx31
  • mrxs10
  • schad
  • sdr5c1
  • HADH2
  • HSD17B10
  • 17b-HSD10
  • ABAD
  • CAMR
  • DUPXp11.22
  • ERAB
  • HCD2
  • MHBD
  • MRPP2
  • MRX17
  • MRX31
  • MRXS10
  • SCHAD
  • SDR5C1
  • 17bHSD10
  • Ads9
  • Hadh2
Epitope
AA 199-235, C-Term
19
7
5
5
4
3
3
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
95
33
32
6
5
2
2
2
2
1
1
1
Host
Rabbit
74
15
14
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
87
39
27
18
17
8
4
2
1
1
1
Supplier
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Immunogen This ABAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-235 AA from the C-terminal region of human ABAD.
Clone RB6481
Isotype Ig
Specificity This ABAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ABAD.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ABAD (HSD17B10 Antibody Abstract)
Background Amyloid b-peptide-binding alcohol dehydrogenase (ABAD) is a member of the family of short chain dehydrogenase/reductases, unique among this family, it binds amyloid b-peptide and exhibits enzymatic activity toward a wide variety of substrates including linear alcohols. In an amyloid beta-abundant environment, ABAD appears to trigger cell stress induced by the amyloid peptide.
Synonyms: hydroxyacyl-Coenzyme A dehydrogenase, type II isoform 1, 3-hydroxyacyl-CoA dehydrogenase type II, Type II HADH, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, Endoplasmic reticulum-associated amyloid beta-peptide binding protein, Short-chain type dehydrogen
Molecular Weight 26923 DA
Gene ID 3028
UniProt Q6IBS9
Research Area Metabolism, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 199-235), (C-Term) antibody (ABIN390286) Western blot analysis of anti-ABAD Pab (ABIN390286) in mouse kidney tissue lysate.ABA...
Immunohistochemistry (IHC) image for anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 199-235), (C-Term) antibody (ABIN390286) Immunohistochemistry on Formalin-fixed and paraffin-embedded human prostate tissue. (...
Western Blotting (WB) image for anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 199-235), (C-Term) antibody (ABIN390286) ABAD Antibody (C214) (ABIN390286) western blot analysis in 293 cell line lysates (35 ...
Background publications Takuma, Yao, Huang et al.: "ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 19, Issue 6, pp. 597-8, 2005 (PubMed).

He, Merz, Mehta et al.: "Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 15014-9, 1999 (PubMed).