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Details for Product No. ABIN391979

Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (C-Term), (AA 1326-1356) antibody

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Antigen
Synonyms FLK1, CD309, VEGFR, VEGFR2, Vegfr-2, FLK-1, flk-1, FLK/KDR, vegfr-2, KDR
Epitope
»Alternatives C-Term, AA 1326-1356
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN391979
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This VEGFR2 (FLK1/KDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1326-1356 AA from the C-terminal region of human VEGFR2 (FLK1/KDR).
Clone RB01536
Isotype Ig
Specificity This VEGFR2 (FLK1/KDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1327~1356 amino acids from the C-terminal region of human KDR/FLK1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name VEGFR2 (FLK1/KDR)
Background KDR (FLK1) is a receptor for VEGF or VEGFC. This protein has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.
Synonyms: Vascular endothelial growth factor receptor 2, VEGFR-2, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, KDR, FLK1
Molecular Weight 151526 DA
Gene ID 3791
UniProt P35968
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IF : 1:10-50,FC : 1:10-50,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Elvert, Kappel, Heidenreich et al.: "Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7520-30, 2003 (PubMed).

Kiba, Yabana, Shibuya: "A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling." in: The Journal of biological chemistry, Vol. 278, Issue 15, pp. 13453-61, 2003 (PubMed).

Zeng, Zhao, Yang et al.: "Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20738-45, 2003 (PubMed).

Yilmaz, Kliche, Mayr-Beyrle et al.: "p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival." in: Biochemical and biophysical research communications, Vol. 306, Issue 3, pp. 730-6, 2003 (PubMed).

Alternatives for antigen "Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)", type "Antibodies"
Hosts (377), (78), (36), (3), (3), (2)
Reactivities (417), (261), (158), (18), (17), (14), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1)
Applications (354), (157), (135), (122), (80), (76), (40), (38), (24), (20), (8), (7), (4), (4), (2), (2), (1)
Conjugates (35), (6), (6), (6), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (45), (39), (39), (26), (19), (16), (12), (11), (10), (7), (7), (6), (6), (5), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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