Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (C-Term), (AA 1326-1356) antibody

Details for Product No. ABIN391979
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Antigen
Synonyms
vegfr-2, KDR, 6130401C07, Flk-1, Flk1, Krd-1, Ly73, VEGFR-2, VEGFR2, sVEGFR-2, Vegfr-2, CD309, FLK1, VEGFR, FLK-1, flk-1, FLK/KDR, flk1, flk1b, kdrb, si:busm1-205d10.1, si:ch211-254j6.1, si:ch211-278f ... show more
vegfr-2, KDR, 6130401C07, Flk-1, Flk1, Krd-1, Ly73, VEGFR-2, VEGFR2, sVEGFR-2, Vegfr-2, CD309, FLK1, VEGFR, FLK-1, flk-1, FLK/KDR, flk1, flk1b, kdrb, si:busm1-205d10.1, si:ch211-254j6.1, si:ch211-278f21.4, wu:fc31a09, fk52c05, flk, kdr, kdra, vegfr2, vegfr4, vegr2, wu:fk52c05 show less
Epitope
C-Term, AA 1326-1356
(59), (45), (38), (38), (28), (22), (17), (16), (15), (13), (10), (9), (8), (8), (6), (6), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(474), (290), (186), (64), (61), (53), (49), (26), (4), (2), (2), (2), (2), (2), (2), (2), (1)
Host
Rabbit
(438), (72), (35), (3), (2), (2), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(33), (15), (12), (10), (9), (6), (6), (6), (6), (6), (6), (6), (6), (6), (3), (3), (3), (3), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)
(375), (173), (167), (112), (84), (77), (60), (47), (31), (24), (10), (7), (7), (4), (3), (1), (1)
Pubmed 4 references available
Quantity 400 μL
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Catalog No. ABIN391979
291.50 $
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Immunogen This VEGFR2 (FLK1/KDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1326-1356 AA from the C-terminal region of human VEGFR2 (FLK1/KDR).
Clone RB01536
Isotype Ig
Specificity This VEGFR2 (FLK1/KDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1327~1356 amino acids from the C-terminal region of human KDR/FLK1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name VEGFR2 (FLK1/KDR)
Background KDR (FLK1) is a receptor for VEGF or VEGFC. This protein has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.
Synonyms: Vascular endothelial growth factor receptor 2, VEGFR-2, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, KDR, FLK1
Molecular Weight 151526 DA
Gene ID 3791
UniProt P35968
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IF = 1:10-50, FACS = 1:10-50, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (C-Term), (AA 1326-1356) antibody Western blot analysis of anti-KDR/FLK1 Pab (ABIN391979) in HeLa cell lysate. KDR (VEGFR2) (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (C-Term), (AA 1326-1356) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Elvert, Kappel, Heidenreich et al.: "Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7520-30, 2003 (PubMed).

Kiba, Yabana, Shibuya: "A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling." in: The Journal of biological chemistry, Vol. 278, Issue 15, pp. 13453-61, 2003 (PubMed).

Zeng, Zhao, Yang et al.: "Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20738-45, 2003 (PubMed).

Yilmaz, Kliche, Mayr-Beyrle et al.: "p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival." in: Biochemical and biophysical research communications, Vol. 306, Issue 3, pp. 730-6, 2003 (PubMed).

Validation Images
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