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IRAK1 antibody (Interleukin-1 Receptor-Associated Kinase 1) (AA 683-712)

Details for Product anti-IRAK1 Antibody No. ABIN392233, Supplier: Log in to see
Antigen
  • AA408924
  • Il1rak
  • IRAK
  • IRAK-1
  • IRAK1
  • IRAK1-S
  • mPLK
  • pelle
  • Plpk
  • RGD1563841
Alternatives
anti-Human IRAK1 antibody for Immunofluorescence
Epitope
AA 683-712, C-Term
39
37
22
22
18
15
14
13
13
13
13
9
8
7
7
6
5
5
5
5
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
247
117
83
Host
Rabbit
230
46
2
Clonality (Clone)
Polyclonal ()
Conjugate
This IRAK1 antibody is un-conjugated
13
11
10
6
6
6
4
4
4
4
4
4
4
4
4
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
197
130
72
46
44
43
33
19
17
16
9
3
2
Supplier
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Immunogen This IRAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 683-712 AA from the C-terminal region of human IRAK.
Clone RB02337
Isotype Ig
Specificity This IRAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 683~712 amino acids from the C-terminal region of human IRAK1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name IRAK (IRAK1 Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine-like kinase (TLK) group consists of 40 tyrosine and serine-threonine kinases such as MLK (mixed-lineage kinase), LISK (LIMK/TESK), IRAK (interleukin-1 receptor-associated kinase), Raf, RIPK (receptor-interacting protein kinase), and STRK (activin and TGF-beta receptors) families.
Synonyms: interleukin-1 receptor-associated kinase 1
Molecular Weight 76536 DA
Gene ID 3654
UniProt P51617
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure
Pathways NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-IRAK1 antibody (Interleukin-1 Receptor-Associated Kinase 1) (AA 683-712) (ABIN392233) Western blot analysis of anti-IRAK1 Pab (ABIN392233) in Jurkat cell lysate. IRAK1 (Ar...
Western Blotting (WB) image for anti-IRAK1 antibody (Interleukin-1 Receptor-Associated Kinase 1) (AA 683-712) (ABIN392233) Western blot analysis of IRAK1 (arrow) using rabbit polyclonal IRAK Antibody (C-term)...
Immunohistochemistry (IHC) image for anti-IRAK1 antibody (Interleukin-1 Receptor-Associated Kinase 1) (AA 683-712) (ABIN392233) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Jensen, Whitehead: "Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 3, pp. 1500-6, 2003 (PubMed).

Jiang, Johnson, Nie, Qin, Bird, Li et al.: "Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 ..." in: The Journal of biological chemistry, Vol. 278, Issue 13, pp. 10952-6, 2003 (PubMed).

Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).