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Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) (C-Term), (AA 452-482) antibody

Details for Product No. ABIN392546
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Antigen
Synonyms KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb, 70kDa
Epitope
C-Term, AA 452-482
(29), (24), (17), (12), (12), (12), (12), (7), (6), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(185), (129), (94), (72), (72), (60), (48), (24)
Host
Rabbit
(176), (17), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(13), (13), (13), (7), (7), (7), (7), (7), (7), (7), (7), (4), (4), (4)
Application
Western Blotting (WB)
(126), (70), (67), (26), (25), (18), (8), (4), (4), (3), (1)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN392546
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Immunogen This p70 S6Kbeta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-482 AA from the C-terminal region of human p70 S6Kbeta.
Clone RB0891
Isotype Ig
Specificity This p70 S6Kbeta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453~482 amino acids from the C-terminal region of human p70 S6Kbeta.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name p70 S6Kbeta
Background This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
Synonyms: Ribosomal protein S6 kinase beta 2, 70 kDa ribosomal protein S6 kinase 2, p70 ribosomal S6 kinase beta, S6 kinase-related kinase, Serine/threonine-protein kinase 14 beta, RPS6KB2, STK14B
Molecular Weight 53483 DA
Gene ID 6199
UniProt Q9UBS0
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) (C-Term), (AA 452-482) antibody Western blot analysis of anti-p70S6Kbeta Pab (ABIN392546) in A375 cell lysate. p70S6Kbeta (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Background publications Gout, Minami, Hara et al.: "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region." in: The Journal of biological chemistry, Vol. 273, Issue 46, pp. 30061-4, 1998 (PubMed).

Saitoh, ten Dijke, Miyazono et al.: "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases." in: Biochemical and biophysical research communications, Vol. 253, Issue 2, pp. 470-6, 1999 (PubMed).

Lee-Fruman, Kuo, Lippincott et al.: "Characterization of S6K2, a novel kinase homologous to S6K1." in: Oncogene, Vol. 18, Issue 36, pp. 5108-14, 1999 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Validation Images
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