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RPS6KB2 antibody (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2) (AA 452-482)

Details for Product anti-RPS6KB2 Antibody No. ABIN392546, Supplier: Log in to see
Antigen
  • 70kDa
  • KLS
  • p70(S6K)-beta
  • P70-beta
  • P70-beta-1
  • P70-beta-2
  • p70S6Kb
  • S6K-beta2
  • S6K2
  • SRK
  • STK14B
Alternatives
anti-Human RPS6KB2 antibody for Immunoprecipitation
Epitope
AA 452-482, C-Term
44
15
14
13
13
13
13
10
6
6
5
5
4
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
208
100
68
Host
Rabbit
191
25
2
Clonality (Clone)
Polyclonal ()
Conjugate
This RPS6KB2 antibody is un-conjugated
16
16
15
7
7
7
4
4
4
4
4
4
4
4
4
Application
Western Blotting (WB)
157
102
46
32
32
22
9
7
3
2
1
1
Supplier
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Immunogen This p70 S6Kbeta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-482 AA from the C-terminal region of human p70 S6Kbeta.
Clone RB0891
Isotype Ig
Specificity This p70 S6Kbeta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453~482 amino acids from the C-terminal region of human p70 S6Kbeta.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name p70 S6Kbeta (RPS6KB2 Antibody Abstract)
Background This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
Synonyms: Ribosomal protein S6 kinase beta 2, 70 kDa ribosomal protein S6 kinase 2, p70 ribosomal S6 kinase beta, S6 kinase-related kinase, Serine/threonine-protein kinase 14 beta, RPS6KB2, STK14B
Molecular Weight 53483 DA
Gene ID 6199
UniProt Q9UBS0
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Signaling, Cell Structure
Pathways PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-RPS6KB2 antibody (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2) (AA 452-482) (ABIN392546) Western blot analysis of anti-p70S6Kbeta Pab (ABIN392546) in A375 cell lysate. p70S6K...
Product cited in: Kroczynska, Mehrotra, Majchrzak-Kita, Arslan, Altman, Stein, McMahon, Kozlowski, Kahle, Eklund, Fish, Platanias: "Regulatory effects of SKAR in interferon ? signaling and its role in the generation of type I IFN responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 31, pp. 11377-82, 2014

Cruz, Hedden, Boyer, Kharas, Fruman, Lee-Fruman: "S6 kinase 2 potentiates interleukin-3-driven cell proliferation." in: Journal of leukocyte biology, Vol. 78, Issue 6, pp. 1378-85, 2005

Background publications Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002

Lee-Fruman, Kuo, Lippincott, Terada, Blenis: "Characterization of S6K2, a novel kinase homologous to S6K1." in: Oncogene, Vol. 18, Issue 36, pp. 5108-14, 1999

Saitoh, ten Dijke, Miyazono, Ichijo: "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases." in: Biochemical and biophysical research communications, Vol. 253, Issue 2, pp. 470-6, 1999

Gout, Minami, Hara, Tsujishita, Filonenko, Waterfield, Yonezawa: "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region." in: The Journal of biological chemistry, Vol. 273, Issue 46, pp. 30061-4, 1998