Mast/stem Cell Growth Factor Receptor (KIT) (AA 934-938) antibody

Details for Product No. ABIN401646
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Antigen
Synonyms Bs, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W, c-KIT, C-Kit, PBT, SCFR, MGF, c-kit
Epitope
AA 934-938
(68), (56), (40), (38), (21), (21), (20), (20), (19), (19), (14), (13), (12), (12), (9), (9), (8), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(673), (357), (141), (100), (98), (91), (22), (7)
Host
Rabbit
(562), (179), (148), (3), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(93), (77), (76), (59), (46), (37), (19), (9), (9), (9), (9), (9), (9), (9), (6), (6), (5), (4), (4), (4), (4), (2), (2), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(318), (300), (296), (142), (121), (97), (90), (33), (31), (26), (24), (16), (13), (10), (9), (7), (3), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN401646
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Immunogen peptide sequence around amino acids 934~938 (H-I-Y-S-N) derived from Human c-kit.
Specificity C-kit Antibody detects endogenous levels of total c-kit protein.
Purification Affinity Chromatography using epitope-specific peptide
Alternative Name CD117 / C-Kit
Background C-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
Gene ID 3815
NCBI Accession NP_000213
UniProt P10721
Research Area CD Antigens, Surface Receptors of Immune Cells, Growth Factors, Receptors, Proliferation Markers
Application Notes Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 934-938) antibody anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 934-938) antibody
Background publications Nocka, Tan, Chiu et al.: "Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W." in: The EMBO journal, Vol. 9, Issue 6, pp. 1805-13, 1990 (PubMed).

Martin, Suggs, Langley et al.: "Primary structure and functional expression of rat and human stem cell factor DNAs." in: Cell, Vol. 63, Issue 1, pp. 203-11, 1990 (PubMed).

Lowe: "Colipase stabilizes the lid domain of pancreatic triglyceride lipase." in: The Journal of biological chemistry, Vol. 272, Issue 1, pp. 9-12, 1997 (PubMed).

Blume-Jensen, Jiang, Hyman et al.: "Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility." in: Nature genetics, Vol. 24, Issue 2, pp. 157-62, 2000 (PubMed).

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