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Caspase 4 antibody (Caspase 4, Apoptosis-Related Cysteine Peptidase) (Intermediate Domain)

Details for Product anti-CASP4 Antibody No. ABIN499563, Supplier: Log in to see
Antigen
  • CASP4
  • ICE(rel)II
  • ICEREL-II
  • ICH-2
  • Mih1/TX
  • TX
  • Casp11
  • Caspl
  • ich-3
  • CASP1
  • CASP13
Alternatives
anti-Human Caspase 4 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
Intermediate Domain
42
26
14
10
6
5
5
5
4
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
163
73
30
20
2
1
1
Host
Rabbit
180
21
15
12
6
Clonality
Polyclonal
Conjugate
This Caspase 4 antibody is un-conjugated
13
11
3
2
2
2
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
189
85
52
43
12
12
11
8
8
5
3
3
1
1
1
Supplier
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Immunogen Human Casp-4 / ICH-2 / ICE rel II / Mih1 (Intermediate Domain) Peptide
Isotype IgG
Specificity Caspase-4 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-4.
Purification Affinity chromatography purified via peptide column
Alternative Name Caspase-4 (CASP4 Antibody Abstract)
Background Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimers disease (5).Synonyms: CASP4, ICE(rel)-II, ICH2, Protease ICH-2, Protease TX
Gene ID 837
UniProt P49662
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes ELISA. Western Blot: Casp-4 antibody can be used for the detection of Caspase-4 at 2 μg/mL. Depending on cell lines or tissues used, other cleavage products may be observed. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 4 antibody (Caspase 4, Apoptosis-Related Cysteine Peptidase) (Intermediate Domain) (ABIN499563) Immunohistochemical staining of human spleen tissue using AP30198PU-N caspase-4 antib...
Western Blotting (WB) image for anti-Caspase 4 antibody (Caspase 4, Apoptosis-Related Cysteine Peptidase) (Intermediate Domain) (ABIN499563) Western blot analysis of caspase-4 in human spleen cells with AP30198PU-N caspase-4 a...
Background publications Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004 (PubMed).

Gracie, Robertson, McInnes: "Interleukin-18." in: Journal of leukocyte biology, Vol. 73, Issue 2, pp. 213-24, 2003 (PubMed).

Kamens, Paskind, Hugunin et al.: "Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases." in: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 15250-6, 1995 (PubMed).

Kuida, Lippke, Ku et al.: "Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme." in: Science (New York, N.Y.), Vol. 267, Issue 5206, pp. 2000-3, 1995 (PubMed).