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Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (C-Term) antibody

Details for Product No. ABIN500998, Supplier: Login to see
Antigen
  • ATAR
  • CD270
  • HVEA
  • HVEM
  • LIGHTR
  • TR2
  • Atar
  • HveA
  • Hvem
  • Tnfrs14
Epitope
C-Term
21
18
10
9
9
9
9
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
147
22
1
Host
Rabbit
78
54
16
8
5
Clonality
Polyclonal
Conjugate
Un-conjugated
14
12
7
6
4
3
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
108
62
55
31
21
11
11
8
8
2
1
1
1
1
Supplier
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Immunogen TNFRSF14 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human TNFRSF14.
Isotype IgG
Specificity This antibody detects TNFRSF14 / HVEM at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Peptide affinity chromatography
Alternative Name TNFRSF14 / HVEM (TNFRSF14 Antibody Abstract)
Background Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-kappaB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.Synonyms: HVEA, Herpesvirus entry mediator A, TR2, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2
Gene ID 8764
UniProt Q92956
Pathways
Application Notes ELISA. Western blot: 1 - 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (C-Term) antibody (ABIN500998) Immunocytochemistry of TNFRSF14 in Raji with this product at 10 μg/ml.
Western Blotting (WB) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (C-Term) antibody (ABIN500998) Western blot analysis of TNFRSF14 in Raji cell lysate with this product at 2 μg/ml in...
Background publications Watts: "TNF/TNFR family members in costimulation of T cell responses." in: Annual review of immunology, Vol. 23, pp. 23-68, 2005 (PubMed).

Mauri, Ebner, Montgomery et al.: "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator." in: Immunity, Vol. 8, Issue 1, pp. 21-30, 1998 (PubMed).

Marsters, Ayres, Skubatch et al.: "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB ..." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14029-32, 1997 (PubMed).

Montgomery, Warner, Lum et al.: "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family." in: Cell, Vol. 87, Issue 3, pp. 427-36, 1996 (PubMed).

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