beta-2 Microglobulin antibody

Catalog No. ABIN636142

Product Details anti-beta-2 Microglobulin Antibody

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This beta-2 Microglobulin antibody is un-conjugated

Application: Please inquire

Specificity: Beta 2 Microglobulin antibody was raised against Human Beta-2-Microglobulin.

Purification: Affinity purified

Purity: > 95 % pure

Sterility: Filtered

Immunogen: Human beta-2-microglobulin
Goat serum was obtained from healthy animals of US origin and under the care of a registered veterinarian.

Application Details

Application Notes: Optimal conditions should be determined byt he investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Clear, colorless liquid, 0.2 µm filtered, containing 10 mM Sodium Phosphate, 0.15 M Sodium Chloride and 0.05 % (w/v) Sodium Azide. Protease/IgG free.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8 °C.

Target Details for beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name: beta 2 Microglobulin (B2M Products)

Synonyms: Ly-m11 antibody, beta2-m antibody, beta2m antibody, bwm antibody, wu:fa94c05 antibody, wu:fb10a09 antibody, b2m-W01 antibody, b2m-W03 antibody, b2m-Z01 antibody, b2m-Z02 antibody, b2m-Z03 antibody, B2M antibody, b2m antibody, B2MG antibody, wu:fb66f11 antibody, wu:fj01f08 antibody, zgc:64161 antibody, b-2-m antibody, beta-2-microglobulin antibody, beta-2 microglobulin antibody, beta-2-microglobulin S homeolog antibody, beta-2-microglobulin, like antibody, B2M antibody, B2m antibody, b2m antibody, b2m.S antibody, b2ml antibody

Background: Beta 2 Microglobulin is a low molecular weight protein with sequence homology to immunoglobulins. As a portion of the HLA complex this protein is an important cell-surface structure. Under normal conditions Beta 2 Microglobulin is synthesized and shed by many cells, particularly lymphocytes, and is detectable in the circulation of normal individuals. Because of its small size it is normally filtered readily at the glomerulus and is catabolized by proximal tubular cells of the kidney. Impaired renal function and hyperproduction of Beta 2 Microglobulin are both associated with increased serum levels. A function for Beta 2 Microglobulin as a modulator of lymphocyte surface and as a potential regulator of the immune system is proposed.

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process