STAT3 antibody (Isoform 1, Isoform 2)

Catalog No. ABIN645873

The Goat not_set anti-STAT3 antibody (ABIN645873) specifically detects STAT3. The antibody is reactive with Mouse and Rat samples.

Quick Overview for STAT3 antibody (Isoform 1, Isoform 2) (ABIN645873)

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Reactivity: Mouse, Rat

Host: Goat

Conjugate: This STAT3 antibody is un-conjugated

Application: Please inquire

Product Details anti-STAT3 Antibody

Binding Specificity: Isoform 1, Isoform 2

Specificity: The STAT3 goat antibody detects protein derived from human recombinant protein and A431 cell lysate at various concentrations.

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Characteristics: Goat Anti-STAT3 (isoform 1 and 2)

Immunogen: Peptide with sequence DMELTSECATSPM, from the C-Terminus of the protein sequence according to NP_003141.2, NP_644805.1 was used as immunogen.

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Reconstitution: Supplied as 100 µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Storage: -20 °C

Target Details for STAT3

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Alternative Name: STAT3

Background: STAT3 is also called as signal transducer and activator of transcription 3 (acutephase response factor), APRF, FLJ20882, MGC16063, DNA-binding protein APRF,acute-phase response factor. The Stat proteins function as both cytoplasmic signal transducers and activators of transcription. The Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family. With the discovery of additional members of the Stat family (Stats3 and 4), the nomenclature has been revised to indicate the Stat family members in the order of their discovery. Stat 91, 84, and 113 have become Stat1alpha, Stat1beta, and Stat2, respectively. Stat3 is a 92kDa protein that is activated as a DNA binding protein through tyrosine phosphorylation in response to treatment of cells with EGF and IL-6 but not with IFN-gamma. Stat3 is widely expressed and can bind to DNA in the absence of Stat1a or Stat2. Stat3 can bind to the sis-inducible element (SIE) site from the c-fos promoter. The site is similar to the GAS element that is present in IFN-gamma induced genes. It appears that Stat3 binds to DNA as a homodimer, but it is also capable of binding as a heterodimer with Stat1. With the isolation of Stat3 and the discovery of Stat4, it appears that the Stat family may contain many members, each with a characteristic tissue distribution and specific activating ligands.

NCBI Accession: NP_644805

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor