BCL2 antibody (B-Cell CLL/lymphoma 2) (AA 169-211)

Details for Product anti-BCL2 Antibody No. ABIN707156, Supplier: Log in to see
Antigen
  • Bcl-2
  • PPP1R50
  • bcl-2
  • AW986256
  • C430015F12Rik
  • D630044D05Rik
  • D830018M01Rik
  • BCL-2
  • Bcl2
  • B-cell CLL/lymphoma 2
  • B cell leukemia/lymphoma 2
  • B-cell leukemia/lymphoma 2
  • B-cell leukemia/lymphoma 2-like
  • B-cell CLL/lymphoma 2 protein
  • BCL2
  • Bcl2
  • LOC100224888
  • bcl2
  • LOC100359045
  • BCL-2
Alternatives
anti-Human BCL2 antibody for Flow Cytometry
Epitope
AA 169-211
164
76
65
62
44
33
25
25
24
21
18
15
15
14
13
13
13
11
9
9
6
6
5
5
5
5
5
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
1032
256
211
53
28
22
18
17
5
4
4
3
2
2
2
2
Host
Rabbit
561
536
19
6
2
2
2
Clonality
Polyclonal
Conjugate
This BCL2 antibody is un-conjugated
50
49
44
38
25
24
22
16
15
14
14
14
14
14
14
14
13
13
13
7
7
7
6
6
6
6
6
6
6
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
814
380
374
329
324
323
228
192
169
80
40
15
14
13
12
11
9
4
3
2
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide derived from human Bcl-2
Isotype IgG
Purification Purified by Protein A.
Alternative Name Bcl-2 (BCL2 Antibody Abstract)
Background

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Subcellular location: Cell membrane

Synonyms: Bcl-2, PPP1R5, Apoptosis regulator Bcl-2, BCL2

Gene ID 596
UniProt P10415
Research Area Cancer, Apoptosis/Necrosis
Pathways MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 169-211) antibody (ABIN707156) Formalin-fixed and paraffin embedded rabbit pancreas labeled with Anti-Bcl-2 Polyclon...
Flow Cytometry (FACS) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 169-211) antibody (ABIN707156) Mouse splenocytes probed with Rabbit Anti-Bcl-2 Polyclonal Antibody, Unconjugated .
Product cited in: Wang, Zhao, Yu, Feng, Zhang, Kou, Chu, Cui, Li, Zhang, Shen, Min: "Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis." in: Toxicology and applied pharmacology, Vol. 313, pp. 149-158, 2016 (PubMed).

Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: "Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways." in: Scientific reports, Vol. 6, pp. 37884, 2016 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Pig (Porcine)).

Huang, Zou, Shi, Zhang, Peng, Zhang, Gao, Wang, Zhang: "Electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 386012, 2015 (PubMed).

Chen, Yan, Wang, Yu, Wang, Zhang, Zhang, Zheng, Zhao, Zheng: "In vivo and in vitro evaluation of effects of Mg-6Zn alloy on apoptosis of common bile duct epithelial cell." in: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2014 (PubMed).

Chen, Luo, Liu, Yuan, Gu, Yang, Li, Tan: "Label-free electrochemical immunoassay of Bcl-2 protein expression on tumor cells." in: Talanta, Vol. 132, pp. 479-85, 2014 (PubMed).

Wang, Ma, Su: "NF-?B pathway contributes to cadmium-induced apoptosis of porcine granulosa cells." in: Biological trace element research, Vol. 153, Issue 1-3, pp. 403-10, 2013 (PubMed).

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