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NLRP12 antibody (N-Term)

NLRP12 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN783719
  • Target See all NLRP12 Antibodies
    NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))
    Binding Specificity
    • 15
    • 8
    • 8
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 50
    • 17
    • 14
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 49
    • 3
    • 1
    Rabbit
    Clonality
    • 50
    • 3
    Polyclonal
    Conjugate
    • 19
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NLRP12 antibody is un-conjugated
    Application
    • 36
    • 33
    • 14
    • 13
    • 13
    • 6
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects NALP2 at N-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    18 amino acid peptide near the amino terminus of human NALP12
    Top Product
    Discover our top product NLRP12 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • Target
    NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))
    Alternative Name
    NALP12 (NLRP12 Products)
    Synonyms
    Nalp12 antibody, NALP12 antibody, CLR19.3 antibody, FCAS2 antibody, PAN6 antibody, PYPAF7 antibody, RNO antibody, RNO2 antibody, NLR family, pyrin domain containing 12 antibody, NLR family pyrin domain containing 12 antibody, NACHT, LRR and PYD domains-containing protein 3 antibody, Nlrp12 antibody, NLRP12 antibody, LOC100018508 antibody
    Background
    NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.Synonyms: LRR and PYD domains-containing protein 12, Monarch-1, NACHT, NLRP12, PYPAF7, PYRIN-containing APAF1-like protein 7, RNO, Regulated by nitric oxide
    Gene ID
    91662
    NCBI Accession
    NP_150639
    UniProt
    P59046
    Pathways
    Positive Regulation of Endopeptidase Activity, Inflammasome
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