Positive Control: Located in the membrane and expressed at high levels in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors.
Purification
Antigen Immunoaffinity purified
Immunogen
Rabbit polyclonal TLR3 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of TLR3.
Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded RNA, as a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as influenza A and West Nile Virus and can mediate entry of at least West Nile virus. Synonyms: