Minichromosome Maintenance Complex Component 6 (MCM6) (AA 79-109), (N-Term) antibody

Details for Product No. ABIN953355, Supplier: Log in to see
Antigen
  • CG4039
  • DmMCM6
  • DmeMCM6
  • Dmel\\CG4039
  • MCM6
  • McM6
  • fs(1)K1214
  • mcm6
  • MCG40308
  • Mis5
  • P105MCM
  • Mcmd6
  • mis5
  • mmcm6
  • ASP-l1
  • D1Wsu22e
  • Minichromosome maintenance 6
  • DNA replication licensing factor MCM6
  • minichromosome maintenance complex component 6
  • minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
  • Protein MCM-6
  • Mcm6
  • TP02_0113
  • PVX_114735
  • CMU_027970
  • MCM6
  • mcm6
  • mcm-6
Alternatives
anti-Human Minichromosome Maintenance Complex Component 6 antibody for BioImaging
Epitope
AA 79-109, N-Term
17
14
10
6
5
4
3
3
2
2
2
1
1
1
Reactivity
Human
88
32
20
17
12
12
10
8
4
2
1
1
1
1
Host
Rabbit
79
7
4
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
82
46
28
26
17
6
5
3
2
1
1
1
1
1
1
Options
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Immunogen KLH conjugated synthetic peptide between 79-109 amino acids from the N-terminal region of human MCM6
Isotype Ig
Specificity This antibody recognizes Human MCM6 (N-term). Other species not tested.
Purification Protein A column, followed by peptide affinity purification
Alternative Name MCM6 (MCM6 Antibody Abstract)
Background The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.Synonyms: DNA replication licensing factor MCM6, Mis5, P105MCM, minichromosome maintenance complex component 6
Molecular Weight 92889 Da
Gene ID 4175
NCBI Accession NP_005906
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA
Pathways DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Minichromosome Maintenance Complex Component 6 (MCM6) (AA 79-109), (N-Term) antibody (ABIN953355) Immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil ti...
Western Blotting (WB) image for anti-Minichromosome Maintenance Complex Component 6 (MCM6) (AA 79-109), (N-Term) antibody (ABIN953355) Western blot analysis of MCM6 Antibody (N-term) in 293 cell line lysates (35ug/lane)....
Background publications Timpson, Brennan, Gaborieau, Moore, Zaridze, Matveev, Szeszenia-Dabrowska, Lissowska, Mates, Bencko, Foretova, Janout, Chow, Rothman, Boffetta, Harbord, Smith: "Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomization." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1341-8, 2010 (PubMed).