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Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 152-181), (Middle Region) antibody

Details for Product No. ABIN954264, Supplier: Log in to see
Antigen
  • 4933429D07Rik
  • AW742785
  • hPPAR
  • LOC100136415
  • nr1c1
  • Nr1c1
  • NR1C1
  • Ppar
  • PPAR
  • PPAR-alpha
  • PPARALPHA
  • PPARalpha
  • xppara
  • xPPARalpha
Alternatives
anti-Mouse (Murine) Peroxisome Proliferator-Activated Receptor alpha antibody for Western Blotting
Epitope
AA 152-181, Middle Region
20
15
15
14
14
14
13
13
10
6
6
5
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
205
125
81
27
24
22
12
8
5
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Host
Rabbit
151
93
Clonality
Polyclonal
Conjugate
Un-conjugated
9
8
7
6
5
5
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
204
100
83
47
38
23
22
14
9
6
5
4
3
2
2
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 152-181 amino acids from the Central region of Human PPAR-alpha Genename: PPARA
Isotype Ig
Specificity This antibody recognizes Human and Mouse PPAR-alpha (Center).
Purification Affinity Chromatography on Protein A
Alternative Name PPAR-alpha (PPARA Antibody Abstract)
Background Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers, this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.Synonyms: NR1C1, Nuclear receptor subfamily 1 group C member 1, PPAR, PPARA, Peroxisome proliferator-activated receptor alpha
Molecular Weight 52225 Da
Gene ID 5465
NCBI Accession NP_001001928
Pathways Nuclear Receptor Transcription Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 152-181), (Middle Region) antibody (ABIN954264) Flow cytometric analysis of CEM cells using PPAR-alpha Antibody (Center) Cat.-No AP53...
Western Blotting (WB) image for anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 152-181), (Middle Region) antibody (ABIN954264) Western blot analysis of PPAR-alpha Antibody (Center) Cat.-No AP53407PU-N in mouse li...
Background publications Jablonski, McAteer, de Bakker, Franks, Pollin, Hanson, Saxena, Fowler, Shuldiner, Knowler, Altshuler, Florez: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010

Hu, Lui, Mak, Chu, Lee, Poon, Tsui, Ko, Baum, Tam, Li, Tomlinson: "Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients." in: Pharmacogenetics and genomics, Vol. 20, Issue 10, pp. 634-7, 2010