Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme (PPP3CC) (N-Term), (AA 17-45) antibody

Details for Product No. ABIN954277
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Antigen
Synonyms CALNA3, CNA3, PP2Bgamma, Calnc, ppp3cc, sb:cb767, si:dkey-21k4.5, calna3, cna3, pp2bgamma
Epitope
N-Term, AA 17-45
(4), (4), (2), (2), (1), (1)
Reactivity
Human
(18), (3), (3)
Host
Rabbit
(16), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
(17), (8), (7), (1), (1)
Pubmed 3 references available
Catalog no. ABIN954277
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of Human PPP3CC
Specificity This antibody recognizes Human PPP3CC / CALNA3 (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name PPP3CC / CALNA3
Background Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1, MIM 114105), calcineurin A-beta (CALNA2, MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).
Alternate names: CAM-PRP catalytic subunit, CNA3, Calcineurin testis-specific catalytic subunit, Calmodulin- dependent calcineurin A subunit gamma isoform, Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, protein phosphatase 2B catalytic subunit gamma
Molecular Weight 58129 Da
Gene ID 5533
NCBI Accession NP_005596
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Liu, Guo, Zhang et al.: "Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity." in: Obesity (Silver Spring, Md.), Vol. 18, Issue 12, pp. 2339-46, 2010 (PubMed).

Saus, Brunet, Armengol et al.: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).

He, Hu, Li et al.: "Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults." in: European journal of applied physiology, Vol. 110, Issue 4, pp. 761-7, 2010 (PubMed).

Hosts (16), (1)
Reactivities (18), (3), (3)
Applications (17), (8), (7), (1), (1)
Epitopes (4), (4), (2), (2), (1), (1)
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