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PPP3CC antibody (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme) (AA 17-45)

Details for Product anti-PPP3CC Antibody No. ABIN954277, Supplier: Log in to see
Antigen
  • calna3
  • CALNA3
  • Calnc
  • CNA3
  • cna3
  • PP2Bgamma
  • pp2bgamma
  • ppp3cc
  • sb:cb767
  • si:dkey-21k4.5
Alternatives
anti-Human PPP3CC antibody for Enzyme Immunoassay
Epitope
AA 17-45, N-Term
24
15
7
2
2
2
2
1
1
1
1
1
Reactivity
Human
51
5
5
Host
Rabbit
49
2
Clonality
Polyclonal
Conjugate
This PPP3CC antibody is un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
48
27
25
11
3
Supplier
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Immunogen KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of Human PPP3CC
Isotype Ig
Specificity This antibody recognizes Human PPP3CC / CALNA3 (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name PPP3CC / CALNA3 (PPP3CC Antibody Abstract)
Background Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1, MIM 114105), calcineurin A-beta (CALNA2, MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95 % amino acid identity).Synonyms: CAM-PRP catalytic subunit, CNA3, Calcineurin testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, protein phosphatase 2B catalytic subunit gamma
Molecular Weight 58129 Da
Gene ID 5533
NCBI Accession NP_005596
Pathways RTK Signaling, WNT Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-PPP3CC antibody (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme) (AA 17-45) (ABIN954277) Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tis...
Western Blotting (WB) image for anti-PPP3CC antibody (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme) (AA 17-45) (ABIN954277) Western blot analysis of PPP3CC / CALNA3 Antibody (N-term) in MDA-MB435 cell line lys...
Background publications Liu, Guo, Zhang, Pei, Yu, Yu, Papasian, Deng: "Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity." in: Obesity (Silver Spring, Md.), Vol. 18, Issue 12, pp. 2339-46, 2010

He, Hu, Li, Bao, Ruiz, Lucia: "Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults." in: European journal of applied physiology, Vol. 110, Issue 4, pp. 761-7, 2010

Saus, Brunet, Armengol, Alonso, Crespo, Fernández-Aranda, Guitart, Martín-Santos, Menchón, Navinés, Soria, Torrens, Urretavizcaya, Vallès, Gratacòs, Estivill: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010