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Details for Product No. ABIN966081

Estrogen Receptor 1 (ESR1) (AA 410-592) antibody

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Antigen
Synonyms
ER, ERa, ESR, Estr, ER[a], Estra, Nr3a1, ERalpha, AA420328, AU041214, ER-alpha, ESRA, ESTRR, Era, NR3A1, Esr, RNESTROR, ERALPHA, ACTGP1, ACT1GP1, HY-psi-gamma-AC6, eralpha, zfER[a], ER[b]1, zfER-beta1 ... show more
Epitope
»Alternatives AA 410-592
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Pubmed 3 references available
Catalog no. ABIN966081
Quantity 0.1 mg
Price
288.75 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Immunogen Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli.
Clone 2B7
Isotype IgG1
Purification Purified
Alternative Name ER-alpha
Background The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.
Synonyms: ER, ESR1, Era, ESRA
Gene ID 2099
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Buffer PBS
Preservative Sodium azide
Storage 4 °C
Product cited in: Pertschuk, Feldman, Kim et al.: "Estrogen receptor immunocytochemistry in paraffin embedded tissues with ER1D5 predicts breast cancer endocrine response more accurately than H222Sp gamma in frozen sections or cytosol-based ligand-binding assays." in: Cancer, Vol. 77, Issue 12, pp. 2514-9, 1996 (PubMed).

Pertschuk, Masood, Simone et al.: "Estrogen receptor immunocytochemistry in endometrial carcinoma: a prognostic marker for survival." in: Gynecologic oncology, Vol. 63, Issue 1, pp. 28-33, 1996 (PubMed).

Paech, Webb, Kuiper et al.: "Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites." in: Science (New York, N.Y.), Vol. 277, Issue 5331, pp. 1508-10, 1997 (PubMed).

Alternatives for antigen "Estrogen Receptor 1 (ESR1)", type "Antibodies"
Hosts (425), (178), (9), (5), (2)
Reactivities (572), (253), (159), (59), (42), (28), (14), (14), (9), (4), (3), (2), (1), (1)
Applications (410), (223), (174), (141), (100), (80), (77), (34), (28), (20), (10), (6), (5), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Conjugates (16), (12), (10), (10), (10), (10), (10), (10), (10), (10), (10)
Epitopes (37), (36), (35), (34), (34), (19), (18), (9), (9), (6), (5), (5), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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