FOXO3 antibody

Catalog No. ABIN966151

This Rabbit Polyclonal antibody specifically detects FOXO3 in IHC. It exhibits reactivity toward Human, Mouse and Rat and has been mentioned in 4+ publications.

Quick Overview for FOXO3 antibody (ABIN966151)

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXO3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-FOXO3 Antibody

Specificity: FKHRL1 (Ab-253) antibody detects endogenous levels of total FKHR1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human FKHR1 around the phosphorylation site of serine 253.

Application Details

Application Notes: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-FOXO3 antibody (ABIN966151)

Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: "Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity." in: The Journal of cell biology, Vol. 169, Issue 2, pp. 331-9, (2005) (PubMed).

Essafi, Fernández de Mattos, Hassen, Soeiro, Mufti, Thomas, Medema, Lam: "Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells." in: Oncogene, Vol. 24, Issue 14, pp. 2317-29, (2005) (PubMed).

Brunet, Park, Tran, Hu, Hemmings, Greenberg: "Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)." in: Molecular and cellular biology, Vol. 21, Issue 3, pp. 952-65, (2001) (PubMed).

Goode, Grauer, Gums: "Infectious vaginitis. Selecting therapy and preventing recurrence." in: Postgraduate medicine, Vol. 96, Issue 6, pp. 85-8, 91-8, (1994) (PubMed).

Target Details for FOXO3

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Alternative Name: FKHRL1

Pathways: Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis