c-MET antibody

Catalog No. ABIN966571

This Rabbit Polyclonal antibody specifically detects c-MET in IHC. It exhibits reactivity toward Human, Mouse and Rat. It has been mentioned in 4+ publications

Quick Overview for c-MET antibody (ABIN966571)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-MET antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-c-MET Antibody

Specificity: Met (Ab-1234) antibody detects endogenous levels of total Met protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Met around the phosphorylation site of tyrosine 1234 (K-E-YP-Y-S).

Application Details

Application Notes: WB: 1:500~1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-c-MET antibody (ABIN966571)

Gherardi, Youles, Miguel, Blundell, Iamele, Gough, Bandyopadhyay, Hartmann, Butler: "Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 21, pp. 12039-44, (2003) (PubMed).

Onuchic, Furu, Nagasawa, Hou, Eggermann, Ren, Bergmann, Senderek, Esquivel, Zeltner, Rudnik-Schöneborn, Mrug, Sweeney, Avner, Zerres, Guay-Woodford, Somlo, Germino: "PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats." in: American journal of human genetics, Vol. 70, Issue 5, pp. 1305-17, (2002) (PubMed).

Shiu, Bleecker: "Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 19, pp. 10763-8, (2001) (PubMed).

Hughes, da Silva, Friedman: "Ancient genome duplications did not structure the human Hox-bearing chromosomes." in: Genome research, Vol. 11, Issue 5, pp. 771-80, (2001) (PubMed).

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: Met

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor