c-MET antibody

Catalog No. ABIN966572

There are 5+ publications for this product available. The Rabbit Polyclonal anti-c-MET antibody is suitable to detect c-MET in samples from Human, Mouse and Rat. It has been validated for IHC.

Quick Overview for c-MET antibody (ABIN966572)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-MET antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-c-MET Antibody

Specificity: Met (Ab-1349) antibody detects endogenous levels of total Met protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Met around the phosphorylation site of tyrosine 1349 (E-H-YP-V-H).

Application Details

Application Notes: WB: 1:500~1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-c-MET antibody (ABIN966572)

Schiering, Knapp, Marconi, Flocco, Cui, Perego, Rusconi, Cristiani: "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 22, pp. 12654-9, (2003) (PubMed).

Fan, Ma, Gao, Yuan, Meng, Goldberg, Rosen: "The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair." in: Molecular and cellular biology, Vol. 21, Issue 15, pp. 4968-84, (2001) (PubMed).

Jackson, Galinha, Pereira, Fortunato, Soares, Amâncio, Pinto Ricardo: "Rapid deposition of extensin during the elicitation of grapevine callus cultures is specifically catalyzed by a 40-kilodalton peroxidase." in: Plant physiology, Vol. 127, Issue 3, pp. 1065-76, (2001) (PubMed).

Plopper, McNamee, Dike, Bojanowski, Ingber: "Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex." in: Molecular biology of the cell, Vol. 6, Issue 10, pp. 1349-65, (1996) (PubMed).

Ponzetto, Bardelli, Maina, Longati, Panayotou, Dhand, Waterfield, Comoglio: "A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor." in: Molecular and cellular biology, Vol. 13, Issue 8, pp. 4600-8, (1993) (PubMed).

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: Met

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor