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GRIN2B antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (AA 892-1051)

Details for Product anti-GRIN2B Antibody No. ABIN967956, Supplier: Log in to see
Antigen
  • AW490526
  • GluN2B
  • hNR3
  • MRD6
  • Nmdar2b
  • nmdar2b
  • NMDAR2B
  • NR2B
  • nr2b
Epitope
AA 892-1051
53
47
39
39
33
27
18
17
14
14
14
13
13
13
12
5
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
304
297
238
15
9
8
5
4
4
4
3
2
2
1
1
Host
Mouse
303
59
15
Clonality (Clone)
Monoclonal ()
Conjugate
This GRIN2B antibody is un-conjugated
12
12
10
9
9
9
9
9
9
9
9
9
5
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
BioImaging (BI), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
256
99
92
76
75
55
48
18
11
4
3
2
1
1
1
Supplier
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Immunogen Rat NMDAR2B aa. 892-1051
Clone 13-NMDAR2B
Isotype IgG2b
Cross-Reactivity Human, Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name NMDAR2B (GRIN2B Antibody Abstract)
Background The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distint types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. Three types of NMDAR2 have been identified: NR2A, NR2B, and NR2C. NR2A and NR2B contain a C-terminal extension (>600 amino acids) that has small scattered regions of conserved sequence. The three NR2 mRNAs show overlapping, differential expression patterns in the rat brain. NR2B has been reported to be expressed in the forebrain, thalamic nuclei, amygdaloid nuclei, caudateputamen, and in restricted regions of the olfactory bulb. This antibody is routinely tested by western blot analysis.
Synonyms: N-Methyl-D-Aspartate Receptor 2B
Molecular Weight 180 kDa
Research Area Neurology, Neurotransmitters, Receptors
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-GRIN2B antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (AA 892-1051) (ABIN967956) Western blot analysis of NMDAR2B on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:5...
Immunofluorescence (IF) image for anti-GRIN2B antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (AA 892-1051) (ABIN967956) Immunofluorescence staining of a rabbit brain section.
 image for anti-GRIN2B antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (AA 892-1051) (ABIN967956) anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 892-1051) antibody (Image 3)
Product cited in: Yoshii, Sheng, Constantine-Paton: "Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 3, pp. 1334-9, 2003 (PubMed).

Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, 2002 (PubMed).

Wong, Setou, Teng, Takei, Hirokawa: "Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 22, pp. 14500-5, 2002 (PubMed).

Sun, Murali: "Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate." in: The American journal of physiology, Vol. 275, Issue 3 Pt 1, pp. C772-9, 1998 (PubMed).

Monyer, Sprengel, Schoepfer, Herb, Higuchi, Lomeli, Burnashev, Sakmann, Seeburg: "Heteromeric NMDA receptors: molecular and functional distinction of subtypes." in: Science (New York, N.Y.), Vol. 256, Issue 5060, pp. 1217-21, 1992 (PubMed).