JAK3 antibody (Tyrosine-Protein Kinase JAK3)

Details for Product anti-JAK3 Antibody No. ABIN969224, Supplier: Log in to see
Antigen
  • JAK-3
  • JAK3_HUMAN
  • JAKL
  • L-JAK
  • LJAK
  • fae
  • wil
  • RATJAK3
  • JAK
  • Janus kinase 3
  • JAK3
  • Jak3
Alternatives
anti-Mouse (Murine) JAK3 antibody for ELISA
Reactivity
Human, Mouse (Murine)
99
64
46
2
2
2
2
2
1
Host
Mouse
71
31
1
Clonality (Clone)
Monoclonal ()
Conjugate
This JAK3 antibody is un-conjugated
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
56
40
27
17
17
12
9
6
6
4
1
1
1
Options
Supplier
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Immunogen Purified recombinant fragment of human JAK3 expressed in E. Coli.
Clone 5H2
Isotype IgG1
Purification Ascites
Alternative Name JAK3 (JAK3 Antibody Abstract)
Background JAK3, Janus kinase 3. It is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Molecular Weight 125 kDa
Gene ID 3718
HGNC 3718
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Flow Cytometry (FACS) image for anti-JAK3 antibody (Tyrosine-Protein Kinase JAK3) (ABIN969224) Figure 1: Flow cytometric analysis of Hela cells using JAK3 mouse mAb (blue) and nega...
Immunocytochemistry (ICC) image for anti-JAK3 antibody (Tyrosine-Protein Kinase JAK3) (ABIN969224) Figure 2: Confocal immunofluorescence analysis of Hela (left) and HepG2 (right) cells...
Immunocytochemistry (ICC) image for anti-JAK3 antibody (Tyrosine-Protein Kinase JAK3) (ABIN969224) Figure 3: Confocal immunofluorescence analysis of 3T3-L1 cells using JAK3 mouse mAb (...
Western Blotting (WB) image for anti-JAK3 antibody (Tyrosine-Protein Kinase JAK3) (ABIN969224) Figure 4: Western blot analysis using JAK3 mouse mAb against Jurkat cell lysate (1) .
Product cited in: Wood, Goodman, Uckun: "Jak3 expression and genomic sequence in pediatric acute lymphoblastic leukemia." in: Leukemia & lymphoma, Vol. 43, Issue 12, pp. 2355-62, 2003 (PubMed).

Background publications Lai, Jin, Graham, Witthuhn, Ihle, Liu: "A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells." in: The Journal of biological chemistry, Vol. 270, Issue 42, pp. 25028-36, 1995 (PubMed).

Kawamura, McVicar, Johnston, Blake, Chen, Lal, Lloyd, Kelvin, Staples, Ortaldo: "Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 14, pp. 6374-8, 1994 (PubMed).