anti-Human Caspase 1 antibody for Immunoprecipitation

Recommended Caspase 1 Antibody (supplied by: Log in to see )

Antigen
Caspase 1 (CASP1) Antibodies
  • ICE
  • IL1BC
  • P45
  • Il1bc
  • Ice
  • CASP1
  • CG5370
  • DCP-1
  • DCP1
  • Dcp1
  • Dmel\\CG5370
  • ccp1
  • dcp-1
  • dcp1
  • l(2)01862
  • l(2)02132
  • caspase 1, apoptosis-related cysteine peptidase
  • caspase 1
  • caspase 4, apoptosis-related cysteine peptidase
  • Death caspase-1
  • caspase-1
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
  • caspase-1-like
  • CASP1
  • Casp1
  • CASP4
  • Dcp-1
  • Ice
  • AaeL_AAEL014348
  • LOC100725217
  • LOC100101588
Reactivity
Human, Mouse (Murine), Rat (Rattus)
253
93
73
8
3
2
2
1
1
1
1
1
1
1
Host
Rabbit
236
40
8
2
Clonality
Polyclonal
Conjugate
This Caspase 1 antibody is un-conjugated
18
14
7
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
253
138
117
84
31
25
16
6
6
5
3
3
1
Options
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Catalog No. ABIN222877
$ 295.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN4288002 ICC IF IP WB Rabbit Log in to see Polyclonal 3
1 ABIN126963 IF IP WB Rabbit Log in to see Polyclonal
1 ABIN2704574 IP IHC WB Rabbit C-Term Log in to see Polyclonal
1 ABIN5611451 IHC (p) IP WB Rabbit Log in to see Polyclonal
1 ABIN1732658 IHC (p) IP IHC WB Rabbit IgG Log in to see Polyclonal
1 ABIN1858235 ICC IHC IP WB Rabbit IgG AA 120-297 Log in to see Polyclonal
1 ABIN1585732 IP IHC ELISA WB Rabbit C-Term Log in to see Polyclonal
1 ABIN241601 IF IP WB Rabbit Log in to see Polyclonal
1 ABIN1001991 IF IP WB Rabbit Log in to see Polyclonal
1 ABIN333789 IP IHC WB Rabbit N-Term Log in to see Polyclonal
1 ABIN200369 ICC IP WB Rabbit AA 225-242 Log in to see Polyclonal
1 ABIN4965102 IF IP WB Rabbit IgG Log in to see Polyclonal
1 ABIN5619046 IHC IP WB Rabbit C-Term Log in to see Polyclonal
1 ABIN2591795 IHC (p) IP WB Rabbit C-Term Log in to see Polyclonal
1 ABIN1077906 ICC IHC IP WB Rabbit IgG AA 120-297 Log in to see Polyclonal
1 ABIN187803 IF IP WB Rabbit Log in to see Polyclonal
1 ABIN2219321 IF IP WB Rabbit IgG Log in to see Polyclonal
1 ABIN4288001 ICC IF IP WB Rabbit Log in to see Polyclonal
1 ABIN2218936 IC IP IHC WB Rabbit IgG AA 224-242 Log in to see Polyclonal
1 ABIN2327673 IP ELISA WB Mouse IgG1 kappa Log in to see 3G225

General

Antigen Caspase 1 (CASP1) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(253), (93), (73), (8), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host Rabbit
(236), (40), (8), (2)
Clonality
Polyclonal
Conjugate This Caspase 1 antibody is un-conjugated
(18), (14), (7), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(253), (138), (117), (84), (31), (25), (16), (6), (6), (5), (3), (3), (1)
Pubmed 5 references available
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Product Details anti-Caspase 1 Antibody

Target Details Caspase 1 Application Details Handling References for anti-Caspase 1 antibody (ABIN222877) Images
Blocking Peptide Blocking peptide for this product available: ABIN412645
Specificity The immunoaffinity purified antibody recognizes 45 kDa procaspase-1 and the 20 kDa cleaved product.
Purification Affinity purified
Immunogen Synthetic peptide surrounding amino acid 132 of human caspase-1
Isotype IgG

Target Details Caspase 1

Product Details anti-Caspase 1 Antibody Application Details Handling References for anti-Caspase 1 antibody (ABIN222877) Images back to top
Antigen
Alternative Name Caspase-1 (CASP1 Antibody Abstract)
Background Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-1 (ICE, interleukin-1β-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1β and IL-18 into active cytokines. Like other caspases, Caspase-1 itself is synthesized as a pro-enzyme that is cleaved during activation into a large (20 kDa) and small (10 kDa) subunits. The cellular role of caspase-1 appears limited to cytokine activation as they do not have obvious roles in apoptosis.
Synonyms: CASP1, IL1BCE, P45, Interleukin-1 beta convertase, IL-1BC, IL1BC, p45, IL1B-convertase, CASP-1, ICE
Gene ID 834
NCBI Accession NP_150636
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Handling References for anti-Caspase 1 antibody (ABIN222877) Images back to top
Application Notes Western blot analysis (0.5-4 μg/mL), immunoprecipitation (4-8 μg/mL) and immunofluorescence (10-20 μg/mL). The immunoaffinity purified antibody recognizes 45 kDa procaspase-1 and the 20 kDa cleaved product.
Restrictions For Research Use only

Handling

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details References for anti-Caspase 1 antibody (ABIN222877) Images back to top
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit anti-caspase-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months

References for anti-Caspase 1 antibody (ABIN222877)

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details Handling Images back to top
Product cited in:

Martin, Shaw, Liu, Steiger, Harper: "MSU crystal-recruited non-inflammatory monocytes differentiate into M1-like pro-inflammatory macrophages in a peritoneal murine model of gout." in: Arthritis and rheumatism, 2011

Martin, Shaw, Liu, Steiger, Harper: "Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout." in: Arthritis and rheumatism, Vol. 63, Issue 5, pp. 1322-32, 2011

Shi, Wang, Li, Sahbaie, Kingery, Clark: "Neuropeptides contribute to peripheral nociceptive sensitization by regulating interleukin-1β production in keratinocytes." in: Anesthesia and analgesia, Vol. 113, Issue 1, pp. 175-83, 2011 (1:200).

Peluffo, Bussmann, Stouffer, Tesone: "Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle." in: Reproduction (Cambridge, England), Vol. 132, Issue 3, pp. 465-75, 2006

Sasaki, Ikeda, Sato, Nakanuma: "Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis." in: The American journal of pathology, Vol. 169, Issue 3, pp. 831-45, 2006

Images

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details Handling References for anti-Caspase 1 antibody (ABIN222877) back to top
Supplier Images
Western Blotting (WB) image for anti-Caspase 1 (CASP1) antibody (ABIN222877) Western blot analysis of Caspase-1 expression in Rat liver tissue lysate.