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anti-Human GZMA antibody for Mass Cytometry

Recommended GZMA Antibody (supplied by: Log in to see )

Antigen
Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) Antibodies
  • AW494114
  • Ctla-3
  • Ctla3
  • CTLA3
  • gzmA
  • GZMA
  • Hf
  • HFSP
  • SE1
  • TSP-1
  • TSP1
Reactivity
Human
106
32
17
1
1
1
Host
Mouse
58
49
14
Clonality
Monoclonal
Conjugate
This GZMA antibody is conjugated to Alexa Fluor 700
7
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Mass Cytometry (CyTOF)
48
34
30
23
19
11
6
4
4
4
3
2
1
1
Supplier
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Available images

Catalog No. ABIN2658092
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Top referenced anti-GZMA antibody for Mass Cytometry

Similar anti-GZMA Antibodies

Application / Reactivity Human
ELISA 29 Antibodies
ELISA (Capture) 1 Antibodies
Flow Cytometry (FACS) 24 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunocytochemistry (ICC) 3 Antibodies
Immunofluorescence (IF) 5 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 22 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 19 Antibodies
Immunoprecipitation (IP) 4 Antibodies
Intracellular Staining (ICS) 2 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Western Blotting (WB) 45 Antibodies

General

Antigen Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) Antibodies
Reactivity Human
(106), (32), (17), (1), (1), (1)
Host Mouse
(58), (49), (14)
Clonality (Clone)
Monoclonal   ( )
Conjugate This GZMA antibody is conjugated to Alexa Fluor 700
(7), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Immunofluorescence (IF), Mass Cytometry (CyTOF)
(48), (34), (30), (23), (19), (11), (6), (4), (4), (4), (3), (2), (1), (1)
Pubmed 9 references available
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Product Details anti-GZMA Antibody

Target Details GZMA Application Details Handling References for anti-GZMA Antibody (ABIN2658092) Images
Purification The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 700 under optimal conditions.
Clone CB9
Isotype IgG1 kappa

Target Details GZMA

Product Details anti-GZMA Antibody Application Details Handling References for anti-GZMA Antibody (ABIN2658092) Images back to top
Antigen
Alternative Name Granzyme A (GZMA Antibody Abstract)
Background Granzyme A is a 28 kD disulfide-linked homodimeric protein and the most abundant of the proteases occurring in CTL granules. It is homologous to other serine esterases, including other granyzmes, mast cell proteases, and neutrophil cathepsins. Granzyme B is thought to be a rapidly-acting apoptotic enzyme, while Granzyme A is slow acting. The CB9 monoclonal antibody recognizes human Granzyme A and has been shown to be useful for flow cytometry, immunoprecipitation, and immunohistochemistry (paraffin-embedded sections).
Research Area Immunology, Innate Immunity, Adaptive Immunity, Apoptosis/Necrosis, Cell/Tissue Markers
Pathways Apoptosis

Application Details

Product Details anti-GZMA Antibody Target Details GZMA Handling References for anti-GZMA Antibody (ABIN2658092) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-GZMA Antibody Target Details GZMA Application Details References for anti-GZMA Antibody (ABIN2658092) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C

References for anti-GZMA Antibody (ABIN2658092)

Product Details anti-GZMA Antibody Target Details GZMA Application Details Handling Images back to top
Background publications

Hersperger, Martin, Shin, Sheth, Kovacs, Cosma, Makedonas, Pereyra, Walker, Kaul, Deeks, Betts: "Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression." in: Blood, Vol. 117, Issue 14, pp. 3799-808, 2011

Chen, Hou, Jiang, Ma, Meng, Wang, Zhang, Zhang, Tang, Zhang, Wan, Li, Yu, Hu, Yang, He, Wang, Cao: "Response of memory CD8+ T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 1, pp. 591-8, 2005

Fan, Beresford, Oh, Zhang, Lieberman: "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor." in: Cell, Vol. 112, Issue 5, pp. 659-72, 2003

Fan, Beresford, Zhang, Xu, Novina, Yoshida, Pommier, Lieberman: "Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A." in: Nature immunology, Vol. 4, Issue 2, pp. 145-53, 2003

Raqib, Ekberg, Sharkar, Bardhan, Zychlinsky, Sansonetti, Andersson: "Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2." in: Infection and immunity, Vol. 70, Issue 6, pp. 3199-207, 2002

Trimble, Lieberman: "Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex." in: Blood, Vol. 91, Issue 2, pp. 585-94, 1998

Beresford, Kam, Powers, Lieberman: "Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 17, pp. 9285-90, 1997

Masson, Tschopp: "A family of serine esterases in lytic granules of cytolytic T lymphocytes." in: Cell, Vol. 49, Issue 5, pp. 679-85, 1987

Brunet, Dosseto, Denizot, Mattei, Clark, Haqqi, Ferrier, Nabholz, Schmitt-Verhulst, Luciani, Golstein: "The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14." in: Nature, Vol. 322, Issue 6076, pp. 268-71, 1986

Images

Product Details anti-GZMA Antibody Target Details GZMA Application Details Handling References for anti-GZMA Antibody (ABIN2658092) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-GZMA antibody (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3))  (Alexa Fluor 700) (ABIN2658092) anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) antibody (Alexa Fluor 700)