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|Application / Reactivity||Mouse (Murine)|
|Flow Cytometry (FACS)||7 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||4 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||4 Antibodies|
|Intracellular Staining (ICS)||4 Antibodies|
|Western Blotting (WB)||12 Antibodies|
|Antigen||Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This GZMA antibody is conjugated to PE Alternatives|
Flow Cytometry (FACS)
|4 references available|
|Supplier||Log in to see|
Product Details anti-GZMA AntibodyTarget Details GZMA Application Details Handling References for anti-GZMA Antibody (ABIN2662739) Images
|Purification||The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details GZMAProduct Details anti-GZMA Antibody Application Details Handling References for anti-GZMA Antibody (ABIN2662739) Images back to top
|Alternative Name||Granzyme A (GZMA Antibody Abstract)|
|Background||Granzyme A is a serine protease that is similar to Granzyme B. However, unlike granzyme B, granzyme A is a homodimer. It is expressed in cytotoxic T cells and natural killer cells (NK), but is not essential for induction of apoptosis or DNA fragmentation. Cell death induced by granzyme A is slower and morphologically different than the cell death induced by granzyme B. It plays a crucial role in infection-mediated inflammation as well as immunological responses against viruses, bacteria, and tumor cells.|
|Research Area||Immunology, Innate Immunity, Adaptive Immunity, Apoptosis/Necrosis, Cell/Tissue Markers|
Application DetailsProduct Details anti-GZMA Antibody Target Details GZMA Handling References for anti-GZMA Antibody (ABIN2662739) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-GZMA Antibody Target Details GZMA Application Details References for anti-GZMA Antibody (ABIN2662739) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-GZMA Antibody (ABIN2662739)Product Details anti-GZMA Antibody Target Details GZMA Application Details Handling Images back to top
Susanto, Stewart, Voskoboinik et al.: "Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis." in: Cell death and differentiation, Vol. 20, Issue 9, pp. 1183-93, 2013 (PubMed).
Fehniger, Cai, Cao et al.: "Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs." in: Immunity, Vol. 26, Issue 6, pp. 798-811, 2007 (PubMed).
Ebnet, Hausmann, Lehmann-Grube et al.: "Granzyme A-deficient mice retain potent cell-mediated cytotoxicity." in: The EMBO journal, Vol. 14, Issue 17, pp. 4230-9, 1995 (PubMed).
Jenne, Tschopp: "Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation." in: Immunological reviews, Vol. 103, pp. 53-71, 1988 (PubMed).
ImagesProduct Details anti-GZMA Antibody Target Details GZMA Application Details Handling References for anti-GZMA Antibody (ABIN2662739) back to top