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anti-Rat (Rattus) Perforin 1 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended Perforin 1 Antibody (supplied by: Log in to see )

Antigen
Perforin 1 (Pore Forming Protein) (PRF1) Antibodies
  • Cyta
  • FLH2
  • HPLH2
  • LOC443187
  • P1
  • perforin
  • Pfn
  • PFN1
  • Pfp
  • PFP
  • Prf-1
  • prf1
  • PRF1
  • RATCYTA
Reactivity
Human, Mouse (Murine), Rat (Rattus)
143
31
16
8
1
1
Host
Rabbit
92
69
14
Clonality
Polyclonal
Conjugate
This Perforin 1 antibody is un-conjugated
18
11
10
4
4
3
3
2
2
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
73
64
34
31
30
17
17
15
14
9
6
6
3
2
2
1
1
1
1
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Catalog No. ABIN1713880
$ 269.50
Plus shipping costs $45.00

Similar anti-Perforin 1 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 2 Antibodies 6 Antibodies
Immunocytochemistry (ICC) 1 Antibodies 6 Antibodies
Immunofluorescence (IF) 2 Antibodies 7 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 1 Antibodies 1 Antibodies
Immunohistochemistry (IHC) 3 Antibodies 7 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 2 Antibodies 4 Antibodies
Immunoprecipitation (IP) 2 Antibodies
Western Blotting (WB) 14 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Flow Cytometry (FACS) 4 Antibodies
Immunochromatography (IC) 4 Antibodies

General

Antigen Perforin 1 (Pore Forming Protein) (PRF1) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(143), (31), (16), (8), (1), (1)
Host Rabbit
(92), (69), (14)
Clonality
Polyclonal
Conjugate This Perforin 1 antibody is un-conjugated
(18), (11), (10), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(73), (64), (34), (31), (30), (17), (17), (15), (14), (9), (6), (6), (3), (2), (2), (1), (1), (1), (1)
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Product Details anti-Perforin 1 Antibody

Target Details Perforin 1 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Perforin
Isotype IgG

Target Details Perforin 1

Product Details anti-Perforin 1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Perforin (PRF1 Antibody Abstract)
Background

The major defense of the body against virus-infected and tumorigenic cells is cytotoxic T lymphocyte (CTL)-mediated cytotoxicity, which also plays a role in autoimmune diseases and transplant rejection. During CTL-mediated cytotoxicity, CTL granules containing perforin are exocytosed. Perforin is a pore-forming protein that facilitates the entry of cytotoxic serine proteases, such as granzymes, into target cells by forming transmembrane channels in target cell membranes. Perforin is primarily expressed in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, but has also been observed in an astrocyte population of the human brain. It has been shown that abrogation of perforin function by Ca2+-complexing agents leads to decreased levels of necrosis, demonstrating that both necrosis and apoptosis contribute to CTL-mediated cytotoxicity. Perforin activity has been shown to be induced by IL-2, IL-3, IL-4, IL-6 and to a lesser degree, TNF and IFN-i³.


Synonyms: Cytolysin, FLH2, HPLH2, Lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1, PERF_HUMAN, Perforin 1, Perforin 1 precursor, Perforin 1 preforming protein, Perforin-1, PFP, PGFL, PIGF, PIGF-2, PLGF, Pore forming protein, PRF 1, PRF1, SHGC-10760.
Gene ID 5551
Research Area Immunology, Innate Immunity, Adaptive Immunity, Inflammation
Pathways Apoptosis, Caspase Cascade in Apoptosis

Application Details

Product Details anti-Perforin 1 Antibody Target Details Perforin 1 Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-Perforin 1 Antibody Target Details Perforin 1 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months