We are preparing the requested document. Please wait, this may take a while...!
|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||4 Antibodies|
|Flow Cytometry (FACS)||87 Antibodies|
|Functional Studies (Func)||25 Antibodies|
|Immunochromatography (IC)||6 Antibodies|
|Immunocytochemistry (ICC)||38 Antibodies|
|Immunofluorescence (IF)||8 Antibodies|
|Immunohistochemistry (IHC)||7 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Immunoprecipitation (IP)||40 Antibodies|
|Intracellular Flow Cytometry (ICFC)||2 Antibodies|
|Neutralization (Neut)||6 Antibodies|
|Western Blotting (WB)||86 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) Antibodies|
|Conjugate||This TNFRSF10A antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-TNFRSF10A AntibodyTarget Details TNFRSF10A Application Details Handling References for anti-TNFRSF10A Antibody (ABIN499762) Images
|Specificity||DR4 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR4 protein.|
|Immunogen||Human DR4 (C-Terminus) Peptide|
Target Details TNFRSF10AProduct Details anti-TNFRSF10A Antibody Application Details Handling References for anti-TNFRSF10A Antibody (ABIN499762) Images back to top
|Alternative Name||CD261 / TRAILR1 (TNFRSF10A Antibody Abstract)|
|Background||Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL2,3, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kappaB activation in many tissues and cells.Synonyms: APO2, DR4, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL receptor 1, TRAIL-R1, Tumor necrosis factor receptor superfamily member 10A|
|Research Area||Signaling, Apoptosis/Necrosis|
Application DetailsProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Handling References for anti-TNFRSF10A Antibody (ABIN499762) Images back to top
ELISA. Western Blot: 1/500 to 1/1000. A 57 kDa band should be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Application Details References for anti-TNFRSF10A Antibody (ABIN499762) Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
References for anti-TNFRSF10A Antibody (ABIN499762)Product Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Application Details Handling Images back to top
Schneider, Thome, Burns et al.: "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB." in: Immunity, Vol. 7, Issue 6, pp. 831-6, 1998 (PubMed).
Pan, ORourke, Chinnaiyan et al.: "The receptor for the cytotoxic ligand TRAIL." in: Science (New York, N.Y.), Vol. 276, Issue 5309, pp. 111-3, 1997 (PubMed).
Wiley, Schooley, Smolak et al.: "Identification and characterization of a new member of the TNF family that induces apoptosis." in: Immunity, Vol. 3, Issue 6, pp. 673-82, 1996 (PubMed).
Pitti, Marsters, Ruppert et al.: "Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12687-90, 1996 (PubMed).
ImagesProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Application Details Handling References for anti-TNFRSF10A Antibody (ABIN499762) back to top