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anti-Human TNFRSF12A antibody for Mass Cytometry

Recommended TNFRSF12A Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
  • AI255180
  • C87282
  • CD266
  • Fn14
  • FN14
  • HPIP
  • TWEAK-R
  • TweakR
  • TWEAKR
Reactivity
Human, Mouse (Murine)
95
43
23
Host
Mouse
49
47
2
Clonality
Monoclonal
Conjugate
This TNFRSF12A antibody is conjugated to Biotin
11
6
4
2
2
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Mass Cytometry (CyTOF)
52
47
19
17
15
14
11
11
3
3
2
1
1
1
Supplier
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Available images

Catalog No. ABIN2661016
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Top referenced anti-TNFRSF12A antibody for Mass Cytometry

Similar anti-TNFRSF12A Antibodies

Application / Reactivity Mouse (Murine) Human
ELISA 6 Antibodies 16 Antibodies
Flow Cytometry (FACS) 23 Antibodies 46 Antibodies
Functional Studies (Func) 11 Antibodies 14 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies 11 Antibodies
Immunohistochemistry (IHC) 7 Antibodies 18 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 3 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 6 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 3 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Western Blotting (WB) 20 Antibodies
Blocking Reagent (BR) 1 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 3 Antibodies

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
Reactivity Human, Mouse (Murine)
(95), (43), (23)
Host Mouse
(49), (47), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF12A antibody is conjugated to Biotin
(11), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Mass Cytometry (CyTOF)
(52), (47), (19), (17), (15), (14), (11), (11), (3), (3), (2), (1), (1), (1)
Pubmed 7 references available
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Product Details anti-TNFRSF12A Antibody

Target Details TNFRSF12A Application Details Handling References for anti-TNFRSF12A Antibody (ABIN2661016) Images
Purification The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Clone ITEM-4
Isotype IgG2b kappa

Target Details TNFRSF12A

Product Details anti-TNFRSF12A Antibody Application Details Handling References for anti-TNFRSF12A Antibody (ABIN2661016) Images back to top
Antigen
Alternative Name CD266 (TNFRSF12A Antibody Abstract)
Background CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia.
Pathways Apoptosis

Application Details

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Handling References for anti-TNFRSF12A Antibody (ABIN2661016) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details References for anti-TNFRSF12A Antibody (ABIN2661016) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-TNFRSF12A Antibody (ABIN2661016)

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling Images back to top
Background publications

Karaca, Swiderska-Syn, Xie, Syn, Krüger, Machado, Garman, Choi, Michelotti, Burkly, Ochoa, Diehl: "TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice." in: PLoS ONE, Vol. 9, Issue 1, pp. e83987, 2014

Muñoz-García, Martín-Ventura, Martínez, Sánchez, Hernández, Ortega, Ortiz, Egido, Blanco-Colio: "Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin." in: Stroke; a journal of cerebral circulation, Vol. 37, Issue 8, pp. 2044-53, 2006

Polek, Talpaz, Darnay, Spivak-Kroizman: "TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 32317-23, 2003

Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, 2002

Feng, Guo, Factor, Thorgeirsson, Bell, Testa, Peifley, Winkles: "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas." in: The American journal of pathology, Vol. 156, Issue 4, pp. 1253-61, 2000

Meighan-Mantha, Hsu, Guo, Brown, Feng, Peifley, Alberts, Copeland, Gilbert, Jenkins, Richards, Winkles: "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration." in: The Journal of biological chemistry, Vol. 274, Issue 46, pp. 33166-76, 2000

Lynch, Wang, Lund, Chen, Leal, Wiley: "TWEAK induces angiogenesis and proliferation of endothelial cells." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8455-9, 1999

Images

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling References for anti-TNFRSF12A Antibody (ABIN2661016) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-TNFRSF12A antibody (Tumor Necrosis Factor Receptor Superfamily, Member 12A)  (Biotin) (ABIN2661016) anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) antibody (Biotin)