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Activation of Mc1r prevents cholesterol uptake and confers protection against macrophage foam cell formation.
MC1-mediated effects were reduced, and MC3 (show MC3R Proteins) anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours.
A melanin-independent interaction between Mc1r and Met signaling pathways is required for hepatocyte growth factor (show HGF Proteins)-dependent melanoma.
In summary, we have identified a new alpha-MSH-MC1R physiologic pathway that reduces HO-induced RPE (show RPE Proteins) cell damage, and might minimize the risk of developing AMD (show AMD1 Proteins).
Absence of Mc1r does not impair the inflammatory response to UV radiation or the generation of immunosuppression.
MC1R decrease the inflammation in vitro and vivo, and might be part of a signaling pathway in inflammatory diseases.
Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.
MC1R regulates melanoma cell migration via inhibition of syndecan-2 (show SDC2 Proteins) expression.
Spatiotemporal localization of MC1R and alpha-MSH in cutaneous wounds warrants future investigation into the role of MC1R/alpha-MSH signaling in the inflammatory and fibroproliferative responses to cutaneous injury.
Data show RNA interference that targets Ube3a (show ube3a Proteins) in P19 (show CDKN2D Proteins) cells caused downregulation of Mc1r and Nr4a2 (show NR4A2 Proteins), whereas overexpression of Ube3a (show ube3a Proteins) results in the upregulation of Mc1r and Nr4a2 (show NR4A2 Proteins).
Variants in MC1R do not play a major role in PD in the Chinese population.
Latin American families had CDKN2A mutations more frequently (P = 0.014) than Spanish ones. Of patients with SMP, 10% of those from Latin America and 8.5% of those from Spain had mutations in CDKN2A (P = 0.623). The most recurrent CDKN2A mutations were c.-34G>T and p.G101W. Latin American patients had fairer hair and skin) and a higher prevalence of MC1R variants compared with Spanish ones
MC1R genetic effects might contribute to sex-specific differences in skin phototype
MC1R may represent a common pathogenic pathway for melanoma and Parkinson disease.
Carriers of MC1R variants were at increased melanoma risk independent of their sun exposure.
This study confirms the presence of CDKN2A and MC1R variants among Cypriot melanomas and supports existing evidence of a role for these variants in susceptibility to melanoma.
Presence of MC1R variant alleles predicted higher levels of dental fear and fear of pain. Importantly, fear of pain mediated the relation between MC1R variant status and dental fear.
this case-control genetic association study using Taiwanese population showed that certain linkage disequilibrium structure of MC1R is strongly associated with vitiligo (show MITF Proteins)
Case Report: MC4R p.Met215del coexisting with FTO and MC1R gene variants, causes severe early onset obesity.
MC1R status is associated with BRAF (show BRAF Proteins)(V600E), BRAF (show BRAF Proteins)(V600K), and NRAS (show NRAS Proteins) mutations in cutaneous melanomas
The e and E+ are the main MC1R haplotypes in taurine or intermediate breeds from China. The haplotypes defined by c.416C>T, c.583C>T and c.890T>C, found mostly in China and Bangladesh, are the typical haplotypes of Bos indicus.
Recombinants in a 5 Mb region surrounding the cluster of tyrosine kinase receptor genes implicated PDGFRA as the strongest positional candidate gene interacting with MC1R and modifying black coat color in an F Nellore-Angus population.
Six solid colors occur in Highland cattle: black, dun, silver dun and red, yellow, and white. These six coat colors are explained by a non-epistatic interaction of the genotypes at the MC1R and PMEL (show PMEL Proteins) genes.
the relationship of polymorphism of the MC1R with coat colour
In China Holstein Black-white Cattle, China Holstein Red-white Cattle, Luxi Yellow Cattle and Bohai Black Cattle, three alleles (ED, E+ and e) in MC1R were identified and important SNP at 725 position of the MC1R coding region was found.
Sequence analysis revealed variation in the TYRP1 (exon 5) and MC1R genes; restriction enzyme analysis of these two genes could distinguish between different colours of Hanwoo cattle.
no significant relationship with behavior at the MC1R locus
The MC1R gene, located on porcine chromosome 6, is responsible for the Extension coat color locus in Sus scrofa.
Melanocortin receptor 1 gene was not the principal factor affecting the coat color differences of Chinese native pig breeds, but could be used to trace the molecular evolution of pig breeds
Mutational analysis of the MC1R loci in relation to coat color.
Variations in the MC1R gene are associated with coat color.
The Chinese Rongchang pig has the dominant black E(D1) allele at the melanocortin 1 receptor (MC1R) locus.
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
, extension recessive yellow
, melanocortin receptor 1
, melanocortin-1 receptor
, melanocyte-stimulating hormone receptor
, tobacco darkening
, melanotropin receptor
, alpha melanocyte stimulating hormone receptor
, melanocortin 1-receptor
, melanocyte stimulating hormone receptor
, melanocortin 1 receptor Mc1r
, melanocortin receptor 5
, melanocortin 1 receptor
, Melanotropin receptor
, Melanocortin receptor 1
, Melanocyte-stimulating hormone receptor