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Full name:
Actinin, alpha 1 Proteins (ACTN1)
On www.antibodies-online.com are 7 Actinin, alpha 1 (ACTN1) Proteins from 5 different suppliers available. Additionally we are shipping ACTN1 Antibodies (79) and ACTN1 Kits (7) and many more products for this protein. A total of 104 ACTN1 products are currently listed.
Synonyms:
3110023F10Rik, actinin, ACTN1, Actn1a, BDPLT15
list all proteins Gene Name GeneID UniProt
ACTN1 87 P12814
ACTN1 109711 Q7TPR4
Rat ACTN1 ACTN1 81634 Q9Z1P2

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ACTN1 Proteins (ACTN1) by Origin

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Human Actinin, alpha 1 (ACTN1) interaction partners

  1. Actinin-1 binds to the C-terminus of A2B adenosine receptor (show ADORA2B Proteins) (A2BAR (show ADORA2B Proteins)) and enhances A2BAR (show ADORA2B Proteins) cell-surface expression

  2. This suggests that a precise dosage of PC2 (show KRT6B Proteins) is necessary for an adequate mechanosensitive alpha-actinin recruitment at junctions.

  3. The present study identified a de novo mutation in ACTA1 (show ACTA1 Proteins) (c.350A>G; p.Asn117Ser) in a Chinese patient using targetcapture sequencing of a panel containing 125 known causal genes for inherited muscle diseases.

  4. Drp1 is in dynamic equilibrium on mitochondria in a fission-independent manner, and that fission factors such as actin filaments target productive oligomerization to fission sites.

  5. Host cortactin, PKD1 and actin are recruited by Trypanosoma cruzi extracellular amastigotes based on experiments in fixed and live cells by time lapse confocal microscopy.

  6. The authors show that the microtubule binding protein EB1 (end-binding protein 1), a key regulator of microtubule dynamics, can bind directly to filamentous actin (F-actin) F-actin.

  7. Several dominantly inherited congenital macrothrombocytopenia-associated mutations that are located within the actinin-1 actin-binding domain cause increased binding of actinin-1 to actin filaments and enhance filament bundling in vitro.

  8. Data indicate that alpha-actinin (110 kDa) autoantibody was characterized as a major target in lupus nephritis (LN) patients positive for Anti-membrane autoantibodies (MbA).

  9. ACTN1 determines the motility of keratinocytes by regulating the organization of the actin cytoskeleton, focal adhesion, and hemidesmosome proteins complexes, thereby modulating cell speed, lamellipodial dynamics, and directed migration

  10. ArgBP2 interaction with alpha-actinin and actin stress fibers inhibits cell migration

Mouse (Murine) Actinin, alpha 1 (ACTN1) interaction partners

  1. Furthermore, this F-actin mesh network attached to the synaptic ribbons directly influences the efficiency of otoferlin-dependent exocytosis and its sensitivity to intracellular hydrostatic pressure.

  2. These findings evidence alpha-actinin involvement in sarcomeric development, suggesting for this protein an important role in stabilizing the muscle contractile apparatus.

  3. The C-terminal polybasic region of CYTH2 (show CYTH2 Proteins) participates in interacting directly with the EFh2 domain of ACTN1.

  4. Actn1 differential methylation occurs in diverse mouse tissues. Authors have found no indication of an imprinted effect on gene expression of Actn1 in mice.

  5. alpha-actinin has a role in adhesion maturation through integrin-dependent force transmission to the extracellular matrix

  6. Alpha-actinin interaction with syndecan-4 (show SDC4 Proteins) has a role in stabilising cell-matrix adhesion.

  7. the SRF-cofilin-actin signaling axis modulates neuronal mitochondrial function

  8. vinculin (show VCL Proteins) engagement of adhesion receptors first activates talin or alpha-actinin, by provoking structural changes that allow their vinculin (show VCL Proteins) binding sites to swing out, which are then sufficient to bind to and activate vinculin (show VCL Proteins)

  9. EFA6A may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines

  10. there is an alpha-actinin-1-dependent mGlu(5b) receptor association with the actin cytoskeleton modulating receptor cell surface expression and functioning

ACTN1 Protein Profile

Protein Summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with ACTN1

  • actinin, alpha 1 (ACTN1)
  • actinin, alpha 1 (actn1)
  • actinin, alpha 1 (Actn1)
  • 3110023F10Rik protein
  • actinin protein
  • ACTN1 protein
  • Actn1a protein
  • BDPLT15 protein

Protein level used designations for Actinin, alpha 1 Proteins (ACTN1)

actinin, alpha 1 , alpha actinin , Alpha-actinin-1 , alpha-actinin-1 , F-actin cross-linking protein , actinin 1 smooth muscle , alpha-actinin cytoskeletal isoform , non-muscle alpha-actinin-1 , alpha actinin 1a , non-muscle alpha-actinin 1 , alpha-actinin 1

GENE ID SPECIES
452993 Pan troglodytes
780123 Xenopus (Silurana) tropicalis
100380299 Salmo salar
100513412 Sus scrofa
100596303 Nomascus leucogenys
87 Homo sapiens
373918 Gallus gallus
109711 Mus musculus
81634 Rattus norvegicus
560400 Danio rerio
399422 Xenopus laevis
480369 Canis lupus familiaris
524770 Bos taurus
100341378 Oryctolagus cuniculus
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