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anti-Human ALOX12B Antibodies:
anti-Mouse (Murine) ALOX12B Antibodies:
anti-Rat (Rattus) ALOX12B Antibodies:
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Human Polyclonal ALOX12B Primary Antibody for ELISA, WB - ABIN559855
Nigam, Zafiriou, Deva, Kerstin, Geilen, Ciccoli, Sczepanski, Lohse: Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form. in FEBS letters 2008
Show all 2 Pubmed References
report adds information on the clinical picture of autosomal recessive congenital ichthyosis (show LBR Antibodies) caused by ALOX12B mutations
We found that the contribution of the ALOX12B gene to the pathogenesis of Autosomal Recessive Congenital Ichthyosis (show LBR Antibodies) to be as important as that of TGM1 (show TGM1 Antibodies) in families of Arab Muslim origin
Loss-of-function mutations in the LOX (show LOX Antibodies) genes ALOX12B and ALOXE3 (show ALOXE3 Antibodies) have been found to represent the second most common cause of autosomal recessive congenital ichthyosis (show LBR Antibodies). [review]
This review covers the background to discovery of the two key lipoxygenases (LOX (show LOX Antibodies)) involved in epidermal barrier function, 12R-LOX and eLOX3 (show ALOXE3 Antibodies). [review]
Autosomal recessive congenital ichthyosis (show LBR Antibodies) patients with NIPAL4 (show NIPAL4 Antibodies) mutations and abnormal ichthyin (show NIPAL4 Antibodies) expression showed increased 12R-LOX and eLOX-3 (show ALOXE3 Antibodies) staining and a colocalization signal of these LOXs that was three times the normal intensity.
It was shown that 12R-lipoxygenase is involved in MUC5AC expression via ERK (show EPHB2 Antibodies)- and Sp1 (show PSG1 Antibodies)-signalling pathways.
co-overproduction of the two chaperones with 12R-LOX resulted in increased solubility of 12R-LOX and allowed the purification of milligram amounts of active enzyme for structural studies by X-ray diffraction
ALOX12B mutations are the leading cause of self-improving collodion ichthyosis (show LBR Antibodies) in Scandinavia, followed by ALOXE3 (show ALOXE3 Antibodies) mutations, and TGM1 (show TGM1 Antibodies) mutations
12-R-LOX (show LOX Antibodies) and COX-2 (show COX2 Antibodies) play critical roles in the regulation of growth in epidermoid carcinoma
Lipoxygenase-3 (ALOXE3 (show ALOXE3 Antibodies)) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.
The 12R-LOX-eLOX-3 (show ALOXE3 Antibodies) pathway plays a key role in the process of epidermal barrier acquisition by affecting lipid metabolism, as well as protein processing.
Alox12b-deficient mouse skin transplants have an ichthyosiform phenotype
This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.
arachidonate 12-lipoxygenase, 12R type
, arachidonate 12-lipoxygenase, 12R-type
, arachidonate 12-lipoxygenase, 12R type-like
, arachidonate 12-lipoxygenase, 12R-type-like
, epidermis-type lipoxygenase 12
, e-LOX 2
, epidermis-type lipoxygenase 2