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anti-Human IRF8 Antibodies:
anti-Mouse (Murine) IRF8 Antibodies:
anti-Rat (Rattus) IRF8 Antibodies:
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Human Polyclonal IRF8 Primary Antibody for ELISA, WB - ABIN1002562
Weisz, Marx, Sharf, Appella, Driggers, Ozato, Levi: Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. in The Journal of biological chemistry 1993
Show all 4 Pubmed References
Human Polyclonal IRF8 Primary Antibody for ELISA, WB - ABIN561405
Conzelmann, Wagner, Hildebrandt, Rodionova, Hess, Zota, Giese, Falk, Ho, Dreger, Hecker, Luft: IFN-? activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production. in Biochemical pharmacology 2010
Cow (Bovine) Polyclonal IRF8 Primary Antibody for WB - ABIN2777225
Ye, Wang, Wang, Wang, Song, Hou, Zhou, Li, Ho: CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes. in Hepatology (Baltimore, Md.) 2009
The vertical and paralleled Pu.1/Spi-b (show SPIB Antibodies) regulatory networks control the development of rostral blood island and ventral wall of dorsal aorta-borne macrophages by regulating Irf8.
Study reveals that specification of all macrophages requires irf8 during an early period of zebrafish hematopoiesis but not during the adult-phase. Also, Irf8 seems to have essential roles in host defense as well.
Irf8 is a critical determinant for neutrophil versus macrophage fate choice during zebrafish primitive myelopoiesis.
IRF8 is dispensable for induced pluripotent stem cell and embryonic stem cell differentiation into hemogenic endothelium and for endothelial-to-hematopoietic transition.
TP(thymidine phosphorylase (show TYMP Antibodies) ) curbed the expression of three proteins-IRF8, RUNX2 (show RUNX2 Antibodies), and osterix (show SP7 Antibodies). This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and increased the methyltransferase DNMT3A's expression
It findings provide evidence for an additional mechanism of epigenetic IRF8 silencing during osteoclastogenesis that likely works cooperatively with DNA methylation (show HELLS Antibodies), further emphasizing the importance of IRF8 as a negative regulator of osteoclastogenesis.
Data suggest that ubiquitin specific protease 4 (USP4 (show USP4 Antibodies)) interacts with interferon regulatory factor 8 (IRF8) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 protein levels in regulatory T-lymphocytes; USP4 (show USP4 Antibodies) and IRF8 are also expressed in helper T-lymphocytes.
these data indicate that human NK cells require IRF8 for development and functional maturation and that dysregulation of this function results in severe human disease, thereby emphasizing a critical role for NK cells in human antiviral defense.
down-regulation of IRF8 in the wound leads to impaired wound healing possibly through the regulation of macrophage function and apoptosis in skin wound.
IRF8 may contribute to the genetic susceptibility of Behcet's disease by regulating IRF8 expression and cytokine production.
IRF5 (show IRF5 Antibodies) and IRF8, two transcription factors with opposing functions, control TLR9 (show TLR9 Antibodies) signaling in human plasmacytoid dendritic cells.
cytarabine-induced upregulation of the IRF8 in leukemic cells involves increased levels of ZNF224 (show ZNF224 Antibodies), which can counteract the repressive activity of WT1 (show WT1 Antibodies) on the IRF8-promoter
Expression of WT1and IRF8 showed a moderate inverse correlation in acute myeloid leukemia (show BCL11A Antibodies) patients. WT1 (show WT1 Antibodies) can be used as an minimal residual disease marker, especially in patients without recurrent genetic abnormalities.
IRF8 does not play an essential intrinsic role in Th17 cell differentiation.
frequencies of antigen-experienced CD4 (show CD4 Antibodies)+CD11ahiCD49dhi cells that were CD44hiCD62L- were similar in MLN (show MLN Antibodies) of infected Irf8-/- and B6 mice, but the proportions of CD4 (show CD4 Antibodies)+GATA3 (show GATA3 Antibodies)+ and CD4 (show CD4 Antibodies)+IL-4 (show IL4 Antibodies)+ T cells were lower in infected Irf8-/- mice
Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.
results show that polymorphonuclear-myeloid-derived suppressor cells arise from a newly defined granulocyte progenitors (GP) stage within the bone marrow and that IRF8 levels (and/or their downstream target genes) in those GPs (show NBEAL2 Antibodies) guide their expansion or contraction
IRF8 differentially controls the survival.
IRF8 might play a role in restraining excess lymphocyte proliferation.
IRF8 controls Th1 immune response in Treg cells independent of T-bet.
The authors further identified a distinct molecular signature of F4/80(hi) and CD11b (show ITGAM Antibodies)(hi) macrophages and found that Irf8 was vital for macrophage maturation.
this study shows that myeloid-specific SIRT1 (show SIRT1 Antibodies) restrains pro-inflammatory processes by deacetylating IRF8
IRF8 was a target of miR (show MLXIP Antibodies)-451a in vitro and in vivo. The data indicate the function and a target of miR (show MLXIP Antibodies)-451a in SLE
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.
, interferon regulatory factor 8
, interferon regulatory factor 8-like
, interferon consensus sequence binding protein 1
, interferon consensus sequence-binding protein
, transcription factor ICSBP
, interferon consensus sequence binding protein