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Human Kallikrein 5 Protein expressed in Escherichia coli (E. coli) - ABIN1098660
Clements, Hooper, Dong, Harvey: The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions. in Biological chemistry 2001
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findings illustrate the crucial role of protease regulation in skin homeostasis and inflammation, and establish KLK5 inhibition as a major therapeutic target for NS
The cloning and characteriazation of recombinant Klk5 is reported.
the expression level of hK5 in tumor stromal cells is a promising biomarker for poor prognosis in TNBC.
This report demonstrates that concurrent loss of KLK5 and KLK7 (show KLK7 Proteins) associates with a poor clinical outcome in Oral Squamous-Cell Carcinoma and could therefore serve as prognostic marker in this disease.
Low KLK5 expression is associated with breast cancer.
KLK5 is an important contributor to the Netherton syndrome proteolytic cascade.
Data indicate that the KLK5 SNP rs268908 was associated with an increased risk of prostate cancer.
Kallikrein 5 and kallikrein 12 (show KLK12 Proteins) cleave human influenza hemagglutinins and activate thrombolytic zymogens.
KLK5 is required for biochemical processing of profilaggrin (show FLG Proteins) in human skin.
the inhibition and binding of different SPINK9 variants towards KLK5, KLK7 (show KLK7 Proteins), KLK8 (show KLK8 Proteins) and KLK14 (show KLK14 Proteins)
Loss of KLK5 is associated with ovarian cancer.
Increased serum and ascitic fluid KLK5 levels are associated with poor patient outcome, thus underlining the importance of KLK5 as a biomarker for early detection as well as for disease management in ovarian cancer.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.
Kallikrein 1 renal/pancreas/salivary
, kallikrein 5
, kallikrein-like protein 2
, stratum corneum tryptic enzyme