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|Antigen||Coagulation Factor II (thrombin) (F2) Antibodies|
|Epitope||Heavy Chain Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Prothrombin antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-Prothrombin AntibodyTarget Details Prothrombin Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human Thrombin heavy chain|
Target Details ProthrombinProduct Details anti-Prothrombin Antibody Application Details Handling Images back to top
|Alternative Name||Thrombin (F2 Antibody Abstract)|
Thrombin is the final protease in the blood coagulation cascade and serves both pro- and anticoagulant functions through the cleavage of several targets. The ability of thrombin to specifically recognize a wide range of substrates derives from interactions which occur outside of the active site of thrombin. Thrombin possesses two anion binding exosites which mediate many of its interactions with cofactors and substrates, and although many structures of thrombin have been solved, few such interactions have been described in molecular detail. Glycosaminoglycan binding to exosite II of thrombin plays a major role in switching off the procoagulant functions of thrombin by mediating its irreversible inhibition by circulating serpins and by its binding to the endothelial cell surface receptor thrombomodulin.
Synonyms: coagulation factor II, prothrombin, F2, Cf-2, Cf2, FII, F 2, coagulation factor II thrombin, Coagulation factor II, Coagulation factor II precursor, F2, Factor II, Factor-II, Prothrombin, prothrombin B-chain, PT, serine protease, THRB, THRB_HUMAN, Thrombin, Thrombin heavy chain.
|Pathways||Complement System, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling|
Application DetailsProduct Details anti-Prothrombin Antibody Target Details Prothrombin Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-Prothrombin Antibody Target Details Prothrombin Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
ImagesProduct Details anti-Prothrombin Antibody Target Details Prothrombin Application Details Handling back to top