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Browse our DNA Repair Protein Complementing XP-G Cells Proteins (ERCC5)

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DNA Repair Protein Complementing XP-G Cells Proteins (ERCC5)
On www.antibodies-online.com are 5 DNA Repair Protein Complementing XP-G Cells (ERCC5) Proteins from 4 different suppliers available. Additionally we are shipping DNA Repair Protein Complementing XP-G Cells Antibodies (67) and DNA Repair Protein Complementing XP-G Cells Kits (7) and many more products for this protein. A total of 85 DNA Repair Protein Complementing XP-G Cells products are currently listed.
Synonyms:
cofs3, ercm2, uvdr, Xpg, xpgc
list all proteins Gene Name GeneID UniProt
ERCC5 2073 P28715
ERCC5 22592  
Rat ERCC5 ERCC5 301382  

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DNA Repair Protein Complementing XP-G Cells Proteins (ERCC5) by Origin

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Human DNA Repair Protein Complementing XP-G Cells (ERCC5) interaction partners

  1. Results show that XPG partners with BRCA1 and BRCA2 (show BRCA2 Proteins) to maintain genomic stability through homologous recombination, and its loss causes DNA breaks, chromosome aberrations, and replication fork stalling.

  2. Helicobacter Pylori introduces double-stranded DNA breaks by the nucleotide excision repair endonucleases XPF and XPG, which, together with RelA (show NFkBP65 Proteins), are recruited to chromatin in a highly coordinated, type IV secretion system-dependent manner.

  3. It has been found that the genotype 751Gln/Gln and allele Gln of ERCC2 (show ERCC2 Proteins) gene and allele Asp (show ASIP Proteins) of 312Asn/Asp (show ASIP Proteins) polymorphism of ERCC2 (show ERCC2 Proteins) gene may be associated with an increased risk of colorectal cancer.

  4. ERCC5 rs17655 polymorphism might contribute to genetic susceptibility to colorectal cancer.

  5. The results suggest that the XPG-TFIIH (show GTF2H1 Proteins) complex is involved in transcription elongation and that defects in this association may partly account for Cockayne syndrome in xeroderma pigmentosum group G/Cockayne Syndrome patients.

  6. XRCC1 (show XRCC1 Proteins) Arg399Gln and XPG His46His might significantly affect the clinical outcomes of platinum-based chemotherapy.

  7. Data show increased risk of leukemia with XPCC (show XPC Proteins) protein (XPC (show XPC Proteins)) 939Gln/Gln genotype, ERCC2 (show ERCC2 Proteins) protein (XPD (show ERCC2 Proteins)) 751Gln allele may be protective against chronic myeloid leukemia (show BCL11A Proteins) and acute myeloid leukemia (show BCL11A Proteins), and no significant risk for the ERCC5 protein (XPG) gene.

  8. our study indicated that ERCC5 rs2094258 polymorphism may contribute to the risk of breast cancer.

  9. XPG Asp1104His polymorphism is a risk factor for head and neck cancer susceptibility.

  10. the rs2296147 and rs2094258 polymorphisms of XPG, could be used as surrogate markers, leading to individualization of non-small cell lung cancer treatment strategies.

Mouse (Murine) DNA Repair Protein Complementing XP-G Cells (ERCC5) interaction partners

  1. HIghlighted in this study is the crucial role of XPG's interactions with TFIIH (show GTF2H4 Proteins) for proper nucleotide excision repair

  2. XPG gene expression can be influenced by an epigenetic mechanism. Restoration of NER (show NR1H2 Proteins) activity through XPG gene transfer or treatment with demethylating agents restored sensitivity to nemorubicin.

  3. introduced a point mutation into the XPG gene which inactivates the nuclease (show DCLRE1C Proteins) catalytic site but leaves the remainder of the protein intact. The mutant mice are hypersensitive to UV irradiation.

  4. Results suggest that the Cockayne syndrome phenotype results from C-terminal truncations in the XPG (xeroderma pigmentosum) gene in mice and humans.

DNA Repair Protein Complementing XP-G Cells (ERCC5) Protein Profile

Protein Summary

This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.

Alternative names and synonyms associated with DNA Repair Protein Complementing XP-G Cells (ERCC5)

  • excision repair cross-complementing rodent repair deficiency, complementation group 5 (ERCC5)
  • excision repair cross-complementing rodent repair deficiency, complementation group 5 (ercc5)
  • excision repair cross-complementing rodent repair deficiency, complementation group 5 (Ercc5)
  • excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome)) (ERCC5)
  • cofs3 protein
  • ercm2 protein
  • uvdr protein
  • Xpg protein
  • xpgc protein

Protein level used designations for ERCC5

DNA repair protein complementing XP-G cells , excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome)) , DNA excision repair protein ERCC-5 , XPG-complementing protein , xeroderma pigmentosum, complementation group G , DNA repair protein complementing XP-G cells homolog , DNA-repair protein complementing XP-G cells homolog , XP-G related factor , xeroderma pigmentosum group G-complementing protein homolog , XPG

GENE ID SPECIES
100226677 Taeniopygia guttata
2073 Homo sapiens
397963 Xenopus laevis
509602 Bos taurus
22592 Mus musculus
301382 Rattus norvegicus
428019 Gallus gallus
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