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Browse our anti-Thymine-DNA Glycosylase (TDG) Antibodies

Full name:
anti-Thymine-DNA Glycosylase Antibodies (TDG)
On www.antibodies-online.com are 57 Thymine-DNA Glycosylase (TDG) Antibodies from 18 different suppliers available. Additionally we are shipping Thymine-DNA Glycosylase Proteins (6) and Thymine-DNA Glycosylase Kits (5) and many more products for this protein. A total of 75 Thymine-DNA Glycosylase products are currently listed.
Synonyms:
5-MCDG, E130317C12Rik, hTDG, JZA-3, Jza1, MGC82456, MGC89441, wu:fb44b11, zgc:110622
list all antibodies Gene Name GeneID UniProt
TDG 21665 P56581
TDG 6996 Q13569
TDG 114521  

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Most Popular Reactivities for anti-Thymine-DNA Glycosylase (TDG) Antibodies

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Top referenced anti-Thymine-DNA Glycosylase Antibodies

  1. Human Polyclonal TDG Primary Antibody for FACS, WB - ABIN390559 : Neddermann, Gallinari, Lettieri, Schmid, Truong, Hsuan, Wiebauer, Jiricny: Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. in The Journal of biological chemistry 1996 (PubMed)
    Show all 2 references for ABIN390559

  2. Human Polyclonal TDG Primary Antibody for EIA, WB - ABIN453411 : Kim, Um: Thymine-DNA glycosylase interacts with and functions as a coactivator of p53 family proteins. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 references for ABIN453411

More Antibodies against Thymine-DNA Glycosylase Interaction Partners

Xenopus laevis Thymine-DNA Glycosylase (TDG) interaction partners

  1. CRL4(Cdt2) targets thymine DNA glycosylase (TDG), a base excision repair enzyme that is involved in DNA demethylation

Mouse (Murine) Thymine-DNA Glycosylase (TDG) interaction partners

  1. The DNA demethylation marks are dynamically regulated in both in vivo and in vitro aging conditions, which are associated with Tet3 (show TET3 Antibodies) over-expression and Tdg repression.

  2. TDG, as a new coactivator, promotes beta-catenin (show CTNNB1 Antibodies)/TCFs transactivation and functionally cooperates with CBP (show CREBBP Antibodies) in canonical Wnt (show WNT2 Antibodies) signaling.

  3. Embryonic lethality in Tdg (-/-) embryos is due, in part, to the reduction of noradrenaline levels.

  4. data suggest that oxidation of 5-methylcytosine by Tet proteins followed by TDG-mediated base excision of 5-carboxylcytosine constitutes a pathway for active DNA demethylation

  5. Results demonstrate that TDG is required for normal mammalian development and the establishment of proper promoter/enhancer DNA methylation (show HELLS Antibodies) patterns that are conducive to transcription during embryogenesis

  6. TDG-dependent DNA repair has evolved to provide epigenetic stability in lineage committed cells

  7. Association of CBP/p300 (show CREBBP Antibodies) acetylase and TDG links DNA repair and transcription.

  8. binds SUM0-1; TDGb was also shown to interact with the promyelocytic leukemia protein (PML (show PML Antibodies)) in vitro as well as to colocalize with this protein to nuclear bodies in transfected cells

  9. TDG sumoylation promotes intramolecular interactions with amino- and carboxy-terminal SUMO-1 (show SUMO1 Antibodies) binding motifs that dramatically alter the biochemical properties and subcellular localization of TDG

  10. Data report the characterization of interactions between Dnmt3b (show DNMT3B Antibodies) and both thymine-DNA glycosylase (Tdg) and methyl-CpG binding domain protein 4 (show MBD4 Antibodies).

Human Thymine-DNA Glycosylase (TDG) interaction partners

  1. Data show that Ras protein regulates inhibitor of growth protein 4 (ING4 (show ING4 Antibodies))-thymine-DNA glycosylase (TDG)-Fas (show FAS Antibodies) protein axis to promote apoptosis resistance in pancreatic cancer.

  2. A long TA repeat in the promoter region of IL28B (show IL28B Antibodies) was associated with spontaneous HCV clearance.

  3. NEIL1 (show NEIL1 Antibodies) and NEIL2 (show NEIL2 Antibodies) cooperate with TDG during base excision: TDG occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG-substrate turnover.

  4. Computational modeling study investigated the glycosidic bond cleavage reaction in human thymine DNA glycosylase

  5. levels of TET3 (show TET3 Antibodies) and TDG mRNAs were independent prognostic factors for early breast cancer patients who received anthracycline chemotherapy

  6. TDG releases the excised base from its tight product complex with abasic DNA, contrary to previous reports. Moreover, DNA-free TDG exhibits no significant binding to free nucleobases (uracil, thymine, 5-hydroxymethyluracil)

  7. these results suggest that individuals harboring the G199S in Thymine DNA glycosylase variant may have increased risk for developing cancer.

  8. Data indicate that both thymine-DNA glycosylase (hTDG) and a second glycosylase, hOGG1, recognized structurally different 8-oxoguanine lesions.

  9. TDG, as a new coactivator, promotes beta-catenin (show CTNNB1 Antibodies)/TCFs transactivation and functionally cooperates with CBP (show CREBBP Antibodies) in canonical Wnt (show WNT2 Antibodies) signaling.

  10. CRL4(Cdt2 (show DTL Antibodies))-dependent degradation of TDG occurs in S phase because of the requirement for TDG to interact with chromatin-loaded PCNA (show PCNA Antibodies), and this degradation is important for preventing toxicity from excess TDG.

Thymine-DNA Glycosylase (TDG) Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.

Alternative names and synonyms associated with Thymine-DNA Glycosylase (TDG)

  • thymine-DNA glycosylase (TDG) antibody
  • thymine-DNA glycosylase (tdg) antibody
  • G/t mismatch-specific thymine DNA glycosylase (Smp_149220) antibody
  • G/T mismatch-specific thymine DNA glycosylase (Tsp_05734) antibody
  • thymine DNA glycosylase (Tdg) antibody
  • thymine-DNA glycosylase (Tdg) antibody
  • 5-MCDG antibody
  • E130317C12Rik antibody
  • hTDG antibody
  • JZA-3 antibody
  • Jza1 antibody
  • MGC82456 antibody
  • MGC89441 antibody
  • wu:fb44b11 antibody
  • zgc:110622 antibody

Protein level used designations for TDG

G/T mismatch-specific thymine DNA glycosylase , G/T mismatch DNA glycosylase , G/t mismatch-specific thymine DNA glycosylase , thymine-DNA glycosylase , G/T mismatch-specific thymine DNA glycosylase-like , g/T mismatch-specific thymine DNA glycosylase-like , C-JUN leucine zipper interactive protein JZA-3

GENE ID SPECIES
395510 Gallus gallus
517825 Bos taurus
553789 Danio rerio
8343678 Schistosoma mansoni
10910381 Trichinella spiralis
399413 Xenopus laevis
448432 Xenopus (Silurana) tropicalis
452188 Pan troglodytes
475448 Canis lupus familiaris
700061 Macaca mulatta
100155184 Sus scrofa
100398863 Callithrix jacchus
100452129 Pongo abelii
100598008 Nomascus leucogenys
21665 Mus musculus
6996 Homo sapiens
114521 Rattus norvegicus
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