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Mouse (Murine) CSK Protein expressed in Baculovirus infected Insect Cells - ABIN3216432
Bräuninger, Holtrich, Strebhardt, Rübsamen-Waigmann: Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases. in Gene 1992
Human CSK Protein expressed in Wheat germ - ABIN1350517
Jo, Park, Lee, Ahn, Kim, Park, Choi: SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. in PLoS ONE 2014
Our results do not support association between PTPN22 (show PTPN22 Proteins)/CSK and Henoch-Schonlein purpura
Results identify CSK downregulation as a principal driver of SRC (show SRC Proteins) activation and castration resistance.
Variant rs1378942 near CSK was nominally associated with systolic blood pressure in a Chinese population.
CSK is the kinase responsible for C-terminal phosphorylation of SRC (show SRC Proteins), but not BRK (show PTK6 Proteins).
Data indicate that the potent c-Src (show SRC Proteins) inhibitors pyrazolo[3,4-d]pyrimidines showed in vivo activity in neuroblastoma (show ARHGEF16 Proteins) xenograft model.
Haemophilus ducreyi LspA1 protein inhibits phagocytosis by activation of host CSK.
In Chinese children, no association of CSK rs1378942, MTHFR (show MTHFR Proteins) rs1801133, CYP17A1 (show CYP17A1 Proteins) rs1004467, STK39 (show STK39 Proteins) rs3754777 and FGF5 (show FGF5 Proteins) rs16998073 with BP/risk of hypertension.
the activity of SIRT2 is regulated by c-Src through post-translational modifications.
Data indicate that the accumulation of the cleaved C-terminal small fragment of eukaryotic elongation factor 2 (eEF2 (show EEF2 Proteins)) in the nucleus, and C-terminal Src kinase (Csk) could enhance the proteolytic cleavage of eEF2 (show EEF2 Proteins).
alpha6beta4 integrin and c-Src activation is important early signaling events to lead mTOR activation and cap-dependent translation of VEGF.
Csk is a causative gene in the 15q24 locus and regulates blood pressure through Src (show SRC Proteins), and these findings provide a novel therapeutic target for the treatment of hypertension
Csk plays an important role, not only in basal signaling, but also in setting the T cell antigen receptor signaling threshold and affinity recognition.
SHIP1 (show INPP5D Proteins) and Csk are part of the PSTPIP2 (show PSTPIP2 Proteins)-dependent inhibitory network that prevents the development of autoinflammatory disease.
If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.
Suggest critical role of Cav1 in modulating cSrc activation, gap junction remodeling, and ventricular arrhythmias.
Differentiation of embryonic stem cells is driven by c-Src (show SRC Proteins) is antagonized by c-Yes (show YES1 Proteins).
critical role in preventing TCR signaling
It was concluded that c-Src (show SRC Proteins) and NADPH oxidase (show NOX1 Proteins) components are necessary for redox-mediated production of TNF-alpha (show TNF Proteins) following liver ischemia-reperfusion and that hepatocytes play an important role in this process.
Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling.
The Csk pathway appears to be a critical signaling cascade regulating social learning and memory
Dok-4 (show DOK4 Proteins) has a role as an anchoring molecule for the tyrosine kinase (show TYRO3 Proteins) c-Src (show SRC Proteins), and in turn as a regulator of TNF-alpha (show TNF Proteins)-mediated ROS (show ROS1 Proteins) production and NF-kappaB (show NFKB1 Proteins) activation
Src (show SRC Proteins) family tyrosine kinases play a central role of arginase and inducible nitric oxide synthase (show NOS2 Proteins) in pulmonary artery endothelium.
Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
, protein-tyrosine kinase CYL
, tyrosine-protein kinase CSK
, protein-tyrosine kinase MPK-2
, C-SRC kinase
, protein-tyrosine kinase (CSK)
, protein kinase
, src kinase