HSD17B1 antibody (AA 29-43)
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- Target See all HSD17B1 Antibodies
- HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))
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Binding Specificity
- AA 29-43
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HSD17B1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- Antigen affinity
- Immunogen
- Amino acids 29-43 (QSFKVYATLRDLKTQ-human) were used as the immunogen for this HSD17B1 antibody.
- Isotype
- IgG
- Top Product
- Discover our top product HSD17B1 Primary Antibody
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anti-Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) (AA 189-285) antibody
HSD17B1 Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 2E5 unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) (AA 1-328) antibodyHSD17B1 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) (AA 29-43), (N-Term) antibodyHSD17B1 Reactivity: Human, Rat WB, ICC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) antibodyHSD17B1 Reactivity: Human, Rat, Mouse IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) (AA 4-289) antibodyHSD17B1 Reactivity: Human WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) (AA 2-261) antibodyHSD17B1 Reactivity: Human WB, ELISA, IF, IP Host: Rabbit Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) (AA 268-328) antibodyHSD17B1 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) (AA 21-120) antibodyHSD17B1 Reactivity: Human, Mouse WB, ELISA, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) antibodyHSD17B1 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1) (N-Term) antibodyHSD17B1 Reactivity: Human, Rat, Mouse, Pig, Cow, Dog, Horse, Guinea Pig, Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- The stated application concentrations are suggested starting amounts. Titration of the HSD17B1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL
- Restrictions
- For Research Use only
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- Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- Storage
- -20 °C
- Storage Comment
- After reconstitution, the HSD17B1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- Target
- HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))
- Alternative Name
- HSD17B1 (HSD17B1 Products)
- Synonyms
- EDH17B2 antibody, EDHB17 antibody, HSD17 antibody, SDR28C1 antibody, 17HSDB1 antibody, 17beta-HSD antibody, E2DH antibody, Hsd17ba antibody, 17BHD1 antibody, zfHSD17B1 antibody, hydroxysteroid 17-beta dehydrogenase 1 antibody, hydroxysteroid (17-beta) dehydrogenase 1 antibody, HSD17B1 antibody, Hsd17b1 antibody, hsd17b1 antibody
- Background
- 17-beta-Hydroxysteroid dehydrogenas I, also known as 17-beta-hydroxysteroid dehydrogenase or 17-ketosteroid reductase, is an enzyme that is responsible for the interconversion of estrone(E1) and estradiol(E2) as well as the interconversion of androstenedione and testosterone. HSD17B1 gene expression is detected in 34 of 42 (81 % ) adenomas in all tumor subtypes, HSD17B2 mRNA is detected in 18 of 42(43 %) adenomas but not in prolactinomas. Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies. All four isoforms are variably expressed in human anterior pituitary adenomas, which also show HSD17B enzyme activity, suggesting that it may play an important role in regulating the local cellular levels of estradiol.
- UniProt
- P14061
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis
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