HSD17B1 antibody (AA 2-261)

Catalog No. ABIN7142296

Product Details anti-HSD17B1 Antibody

Target: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Binding Specificity: AA 2-261

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2 protein (2-261AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HSD17B1

Target: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Alternative Name: HSD17B1 (HSD17B1 Products)

Synonyms: EDH17B2 antibody, EDHB17 antibody, HSD17 antibody, SDR28C1 antibody, 17HSDB1 antibody, 17beta-HSD antibody, E2DH antibody, Hsd17ba antibody, 17BHD1 antibody, zfHSD17B1 antibody, hydroxysteroid 17-beta dehydrogenase 1 antibody, hydroxysteroid (17-beta) dehydrogenase 1 antibody, HSD17B1 antibody, Hsd17b1 antibody, hsd17b1 antibody

Background:

Background: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5\\\'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

Aliases: 17 beta hydroxysteroid dehydrogenase 10 antibody, 17 beta hydroxysteroid dehydrogenase type 10 antibody, 17-beta-HSD 10 antibody, 17-beta-hydroxysteroid dehydrogenase 10 antibody, 17b HSD10 antibody, 3 hydroxy 2 methylbutyryl CoA dehydrogenase antibody, 3 hydroxyacyl CoA dehydrogenase type 2 antibody, 3 hydroxyacyl CoA dehydrogenase type II antibody, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase antibody, 3-hydroxyacyl-CoA dehydrogenase type II antibody, 3-hydroxyacyl-CoA dehydrogenase type-2 antibody, AB binding alcohol dehydrogenase antibody, ABAD antibody, Ads9 antibody, Amyloid beta binding polypeptide antibody, Amyloid beta peptide binding alcohol dehydrogenase antibody, Amyloid beta peptide binding protein antibody, Amyloid beta peptide binding protein antibody, CAMR antibody, DUPXp11.22 antibody, Endoplasmic Reticulum Amyloid Binding Protein antibody, Endoplasmic reticulum associated amyloid beta peptide binding protein antibody, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein antibody, ER associated amyloid beta-binding protein antibody, ERAB antibody, HADH 2 antibody, HADH2 antibody, HCD 2 antibody, HCD2 antibody, HCD2_HUMAN antibody, Hsd17b10 antibody, Hydroxyacyl CoA Dehydrogenase type II antibody, Hydroxyacyl Coenzyme A dehydrogenase type II antibody, Hydroxysteroid (17 beta) dehydrogenase 10 antibody, Mental retardation X linked syndromic 11 antibody, MHBD antibody, Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase antibody, Mitochondrial ribonuclease P protein 2 antibody, Mitochondrial RNase P protein 2 antibody, MRPP2 antibody, MRX17 antibody, SCHAD antibody, SDR5C1 antibody, Short chain dehydrogenase/reductase family 5C member 1 antibody, Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 antibody, Short chain type dehydrogenase/reductase XH98G2 antibody, Short-chain type dehydrogenase/reductase XH98G2 antibody, Type 10 17b HSD antibody, Type 10 17beta hydroxysteroid dehydrogenase antibody, Type II HADH antibody, XH98G2 antibody

UniProt: Q99714

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis