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MBD4 antibody (AA 323-351)

MBD4 Reactivity: Human WB Host: Rabbit Polyclonal RB40399 unconjugated
Catalog No. ABIN1881532
  • Target See all MBD4 Antibodies
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Binding Specificity
    • 9
    • 9
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 323-351
    Reactivity
    • 32
    • 5
    • 3
    • 1
    Human
    Host
    • 31
    • 1
    • 1
    Rabbit
    Clonality
    • 32
    • 1
    Polyclonal
    Conjugate
    • 16
    • 4
    • 4
    • 3
    • 3
    • 3
    This MBD4 antibody is un-conjugated
    Application
    • 26
    • 24
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This MBD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-351 amino acids from the Central region of human MBD4.
    Clone
    RB40399
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Arora, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Thyagarajan: "Polymorphisms in the base excision repair pathway and graft-versus-host disease." in: Leukemia, Vol. 24, Issue 8, pp. 1470-5, (2010) (PubMed).

    Thyagarajan, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Arora: "Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations." in: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, Vol. 16, Issue 8, pp. 1084-9, (2010) (PubMed).

    Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

  • Target
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Alternative Name
    MBD4 (MBD4 Products)
    Synonyms
    MED1 antibody, Med1 antibody, methyl-CpG binding domain 4, DNA glycosylase antibody, methyl-CpG binding domain protein 4 antibody, methyl-CpG binding domain 4 DNA glycosylase antibody, MBD4 antibody, Mbd4 antibody
    Background
    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.
    Molecular Weight
    66051
    NCBI Accession
    NP_001263199, NP_001263201, NP_001263202, NP_003916
    UniProt
    O95243
    Pathways
    DNA Damage Repair
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