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Activating transcription factor 6 (ATF6alpha) pathway and ER-associated protein degradation (ERAD) are elevated in salivary glands of Sjogren's syndrome patients (SS).
A transcription factor complex consisting of ATF6 (an endoplasmic reticulum-resident factor) and C/EBP-beta (show CEBPB ELISA Kits) is required for the IFN-gamma-induced (show SAMHD1 ELISA Kits) expression of DAPK1 (show DAPK1 ELISA Kits) IFN-gamma-induced (show SAMHD1 ELISA Kits) proteolytic processing of ATF6 and phosphorylation of C/EBP-beta (show CEBPB ELISA Kits) are obligatory for the formation of this transcriptional complex
Authors observed the cleavage of ATF6, the phosphorylation of MRLC, and the expression of death-associated protein kinase (DAPK1 (show DAPK1 ELISA Kits)) by western blotting; the transcription of DAPK1 (show DAPK1 ELISA Kits) by RT-PCR; and the subcellular localization of ATF6 and mAtg9 (show ATG9A ELISA Kits) by immunofluorescence.
Genetic Variations in ATF6 (rs2070150) is not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection.
We found that HCS (show HLCS ELISA Kits) identified compounds which inhibited ATF6 nuclear translocation with high specificity, as confirmed by the luciferase reporter assay and western blot analysis
results identify a role for DREAM silencing in the activation of ATF6 signaling, which promotes early neuroprotection in HD.
Endoplasmic reticulum stress related factor ATF6 and caspase-12 (show CASP12 ELISA Kits) trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Defective podocyte insulin (show INS ELISA Kits) signaling through p85-XBP1 (show XBP1 ELISA Kits) promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
protein expression were significantly higher in the placentas of women with early and late SPE than in the control women, whereas there were no differences in ATF6 and Ire1 (show ERN1 ELISA Kits) mRNA and protein.
autosomal recessive achromatopsia is caused by a frameshift mutation in ATF6 in this Pakistani family
Deletion of Atf6alpha suppressed inflammation, and ameliorated demyelination after experimental autoimmune encephalomyelitis.
we show that overexpression of the dominant-negative form of ATF6 (dnATF6) increases susceptibility to develop hepatic steatosis in diet-induced insulin (show INS ELISA Kits)-resistant mice and fasted mice. Furthermore, hepatic overexpression of the active form of ATF6 promotes hepatic fatty acid oxidation and protects against hepatic steatosis in diet-induced insulin (show INS ELISA Kits)-resistant mice.
The present study extends our understanding and provides new insights into the physiological significance of ATF6, a key signal transducer of ER stress, in ovarian granulosa cells.
ATF6 serves as an important role between ER stress and oxidative stress, by decreasing myocardial ischemia/reperfusion damage.
ATF6alpha mRNA and protein levels were higher in the uterus near the implantation site following embryo implantation.
ATF6a favorably controls chondrogenesis and bone formation (1) by acting as a co-factor of Runx2 (show RUNX2 ELISA Kits) and enhancing Runx2 (show RUNX2 ELISA Kits)-incited hypertrophic chondrocyte differentiation, and (2) by affecting IHH (show IHH ELISA Kits) and PTHrP (show PTHLH ELISA Kits) signaling.
Data show that EIF2AK3/PERK (show EIF2AK3 ELISA Kits)-mediated downregulation of miR (show MLXIP ELISA Kits)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 ELISA Kits) protein and activating transcription factor 6 (ATF6) during conditions of endoplasmic reticulum stress.
Our results suggest that ATF6alpha plays an important role in neuronal survival after KA-induced excitotoxicity through the regulation of Ca(2 (show CA2 ELISA Kits)+) response and neuronal activity
ATF6alpha regulates the expression of endoplasmic reticulum chaperones, C/EBP homologous protein (show DDIT3 ELISA Kits), and ER-associated degradation components
Exposure of endothelial cells to VEGF (show VEGFA ELISA Kits), high glucose, or hydrogen peroxide up-regulated the XBP1 (show XBP1 ELISA Kits)/IRE1 alpha (show ERN1 ELISA Kits) and ATF6 arms of the unfolded protein response compared with untreated cells.
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
activating transcription factor 6
, cyclic AMP-dependent transcription factor ATF-6 alpha-like
, cAMP-dependent transcription factor ATF-6 alpha
, cyclic AMP-dependent transcription factor ATF-6 alpha