Browse our anti-INSIG2 (INSIG2) Antibodies

Full name:
anti-Insulin Induced Gene 2 Antibodies (INSIG2)
On are 24 Insulin Induced Gene 2 (INSIG2) Antibodies from 7 different suppliers available. Additionally we are shipping INSIG2 Proteins (4) and many more products for this protein. A total of 30 INSIG2 products are currently listed.
2900053I11Rik, C730043J18Rik, Insig-2, MGC82156
list all antibodies Gene Name GeneID UniProt
INSIG2 51141 Q9Y5U4
INSIG2 72999 Q91WG1
INSIG2 288985 Q80UA9

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anti-Human INSIG2 Antibodies:

anti-Mouse (Murine) INSIG2 Antibodies:

anti-Rat (Rattus) INSIG2 Antibodies:

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Top referenced anti-INSIG2 Antibodies

  1. Cow (Bovine) Polyclonal INSIG2 Primary Antibody for WB - ABIN2778637 : Li, Gruidl, Eschrich, McCarthy, Wang, Alexandrow, Yeatman: Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis. in International journal of cancer. Journal international du cancer 2008 (PubMed)
    Show all 2 references for 2778637

  2. Human Polyclonal INSIG2 Primary Antibody for WB - ABIN4892461 : Segatto, Di Giovanni, Marino, Pallottini: Analysis of the protein network of cholesterol homeostasis in different brain regions: an age and sex dependent perspective. in Journal of cellular physiology 2013 (PubMed)

More Antibodies against INSIG2 Interaction Partners

Human Insulin Induced Gene 2 (INSIG2) interaction partners

  1. INSIG2 plays a role in weight gain and obesity during clozapine treatment

  2. These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR (show HMGCR Antibodies) are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  3. There may be a connection between INSIG2 expression and metastatic dissemination of colorectal cancer without any effect on tumorigenesis.

  4. Insulin (show INS Antibodies) resistance in obese boys leads to up-regulation of INSIG2 gene expression as well as to down-regulation of PFKFB1 (show PFKFB1 Antibodies), PFKFB3 (show PFKFB3 Antibodies), and HK2 (show HK2 Antibodies) genes in the blood cells as compared to obese patients with normal insulin (show INS Antibodies) sensitivity.

  5. Results confirmed that genetic variation in INSIG2 is associated with both overweight and LDL in non-Hispanic white children.

  6. This study suggests that the G allele in the INSIG2 single nucleotide polymorphism rs7566605 is more relevant for changes in intramuscular adipose tissue following training than for the amount of subcutaneous fat.

  7. INSIG2 is involved in adipogenesis and MC4R (show MC4R Antibodies) effects hormonal appetite control in response to the amount of adipose tissue.

  8. The results provided evidence for identifying genetic factors of nonalcoholic fatty liver disease (NAFLD (show TSC2 Antibodies)) and may be useful for risk assessment and personalized medicine of NAFLD (show TSC2 Antibodies).

  9. The INSIG2 rs7566605 SNP may not play a role in the development of obesity-related metabolic traits in Malaysian Malays.

  10. identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.

Pig (Porcine) Insulin Induced Gene 2 (INSIG2) interaction partners

  1. FASN (show FASN Antibodies) gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 is a promising marker for FA composition

Mouse (Murine) Insulin Induced Gene 2 (INSIG2) interaction partners

  1. INSIG2 is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in livers of Ob/Ob mice, both systems of elevated SREBP-1c (show SREBF1 Antibodies)-driven lipogenesis.

  2. These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR (show HMGCR Antibodies) are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  3. Data show that REV-ERBalpha (show NR1D1 Antibodies) participates in the circadian modulation of SREBP activity, and the expression of SREBP target genes involved in cholesterol and lipid metabolism via the cyclic transcription of Insig2.

  4. Liver-specific mRNA for Insig-2 down-regulated by insulin (show INS Antibodies): implications for fatty acid synthesis.

  5. a vitamin D response element in the murine Insig-2 promoter may have a role in the differentiation of 3T3-L1 preadipocytes

  6. Insig2 identified as a strong candidate susceptibility gene for total plasma cholesterol levelsin inbred mice strains

  7. Treatment of pregnant mice with the HMG-CoA reductase (show HMGCR Antibodies) inhibitor lovastatin reduced sterol synthesis in Insig2-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.

  8. A critical gene involved in cholesterol homeostasis, Insig-2, was induced when mice or cultured cells were treated with FXRalpha (show NR1H4 Antibodies) agonists or infected with constitutively active FXRalpha (show NR1H4 Antibodies).

  9. Peroxisome deficiency causes a complex phenotype because of hepatic SREBP-1c (show SREBF1 Antibodies),-2/Insig-2a,b dysregulation associated with endoplasmic reticulum stress

  10. Silibinin inhibits adipocyte differentiation through a potential up-regulation of insig-1 (show INSIG1 Antibodies) and insig-2 at an early phase in adipocyte differentiation.

INSIG2 Antigen Profile

Antigen Summary

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.

Alternative names and synonyms associated with INSIG2

  • insulin induced gene 2 (insig2) antibody
  • insulin induced gene 2 (INSIG2) antibody
  • insulin induced gene 2 (Insig2) antibody
  • 2900053I11Rik antibody
  • C730043J18Rik antibody
  • Insig-2 antibody
  • MGC82156 antibody

Protein level used designations for INSIG2

insulin-induced gene 2 protein , INSIG-2 , insulin-induced gene 2 protein-like , insulin induced gene 2 , INSIG2 membrane protein , insulin induced protein 2 , insulin-induced membrane protein 2 , INSIG-2 membrane protein , Insulin-induced gene 2 protein

399645 Danio rerio
447512 Xenopus laevis
496587 Xenopus (Silurana) tropicalis
693654 Macaca mulatta
743385 Pan troglodytes
51141 Homo sapiens
100170127 Sus scrofa
534440 Bos taurus
72999 Mus musculus
288985 Rattus norvegicus
610496 Canis lupus familiaris
424276 Gallus gallus
100173587 Pongo abelii
100137376 Papio anubis
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