Browse our AKT1 Substrate 1 (Proline-Rich) (AKT1S1) ELISA Kits

On are 12 AKT1 Substrate 1 (Proline-Rich) (AKT1S1) ELISA Kits from 5 different suppliers available. Additionally we are shipping AKT1 Substrate 1 (Proline-Rich) Antibodies (97) and AKT1 Substrate 1 (Proline-Rich) Proteins (5) and many more products for this protein. A total of 124 AKT1 Substrate 1 (Proline-Rich) products are currently listed.
1110012J22Rik, AI227026, fb34a04, Lobe, Lobel, MGC81452, PRAS40, wu:fb34a04
list all ELISA KIts Gene Name GeneID UniProt
AKT1S1 84335 Q96B36
AKT1S1 67605 Q9D1F4
AKT1S1 292887  

AKT1 Substrate 1 (Proline-Rich) (AKT1S1) ELISA Kits by Reactivity

More ELISA Kits for AKT1 Substrate 1 (Proline-Rich) Interaction Partners

Human AKT1 Substrate 1 (Proline-Rich) (AKT1S1) interaction partners

  1. PRAS40 was downregulated in the DU145 cells following MYO6 (show MYO6 ELISA Kits) knockdown.

  2. Phosphorylation of S202/203 of AKT1S1 by PKM2 released AKT1S1 from raptor (show RPTOR ELISA Kits) and facilitated its binding to 14-3-3 (show YWHAQ ELISA Kits), resulted in hormonal- and nutrient-signals independent activation of mTORC1 signaling and led accelerated oncogenic growth and autophagy inhibition in cancer cells.

  3. The frameshift mutation detected in the current study would result in a premature stop of amino-acid synthesis in AKT1S1 protein and hence resembles a typical loss-of-function mutation.

  4. Supporting this idea, we identified a downstream target of the TGFb (show TGFB1 ELISA Kits)-miR (show MLXIP ELISA Kits)-96 signaling pathway to be AKT1S1 mRNA, whose translated protein is a negative regulator of mTOR (show FRAP1 ELISA Kits) kinase.

  5. This review discusses the role of PRAS40 and possible feedback mechanisms, and alterations in AKT (show AKT1 ELISA Kits)/PRAS40/mTOR (show FRAP1 ELISA Kits) signaling that have been implicated in the pathogenesis of tumor progression. [review]

  6. Findings indicate that dual phosphorylation of PRAS40 by Akt (show AKT1 ELISA Kits) and mTORC1 promotes formation of a nuclear-specific PRAS40- and RPL11 (show RPL11 ELISA Kits)-containing complex distinct from mTORC1 that inhibits the RPL11 (show RPL11 ELISA Kits)-HDM2-p53 (show TP53 ELISA Kits) pathway.

  7. PRAS40 as a regulator of insulin (show INS ELISA Kits) sensitivity in hSkMC

  8. PRAS40 contains a functional nuclear export signal. Furthermore, enforced nuclear accumulation of PRAS40 impairs insulin (show INS ELISA Kits) action, thereby substantiating the function of this protein in the regulation of insulin (show INS ELISA Kits) sensitivity.

  9. Data suggest that PRAS40 modulates insulin (show INS ELISA Kits) action in skeletal muscle; knockdown of PRAS40 inhibits insulin (show INS ELISA Kits) action in cultured myotubes and is associated with up-regulation of IRS1 (insulin receptor substrate 1 (show IRS1 ELISA Kits)) degradation via proteasome proteolysis.

  10. WISP1 (show WISP1 ELISA Kits) governs PRAS40 by sequestering PRAS40 intracellularly through post-translational phosphorylation.

Mouse (Murine) AKT1 Substrate 1 (Proline-Rich) (AKT1S1) interaction partners

  1. Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development

  2. PRAS40 inhibits mTORC1 hyperactivation and plays a key role in protecting cells against neurotoxic prion (show PRNP ELISA Kits) peptide-induced apoptosis. Thus, PRAS40 is a potential therapeutic target for prion (show PRNP ELISA Kits) disease.

  3. PRAS40 appears to reduce brain injury following ischemic stroke by converting cell signaling from Akt (show AKT1 ELISA Kits) to mTOR (show FRAP1 ELISA Kits)

  4. PRAS40 treatment improves hepatic insulin (show INS ELISA Kits) sensitivity and reduces systemic hyperglycaemia in obese mice.

  5. PRAS40 phosphorylation acts as a molecular switch allowing mTORC1 activation during physiological growth, opening up unique possibilities for therapeutic regulation of the mTORC1 complex to mitigate pathologic myocardial hypertrophy by PRAS40

  6. Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR (show FRAP1 ELISA Kits)) activity via a PRAS40-mediated mechanism.

  7. These results suggest that a reduction in PRAS40 specifically impairs myoblast protein synthesis, cell cycle, proliferation and differentiation to myotubes.

  8. PRAS phosphorylation and its interaction with pAkt (show AKT1 ELISA Kits) and 14-3-3 (show YWHAQ ELISA Kits) might play an important role in neuroprotection mediated by NGF (show NGFB ELISA Kits) in apoptotic neuronal cell death after transient focal cerebral ischemia

  9. overexpression of SOD1 (show SOD1 ELISA Kits) may affect the PRAS pathway after transient focal cerebral ischemia by reducing the direct oxidative reaction to pPRAS after reperfusion injury

  10. PRAS40 is an important regulator of insulin (show INS ELISA Kits) sensitivity of the Akt (show AKT1 ELISA Kits)-mTOR (show FRAP1 ELISA Kits) pathway and a potential target for the treatment of cancers, insulin (show INS ELISA Kits) resistance and hamartoma syndromes.

AKT1 Substrate 1 (Proline-Rich) (AKT1S1) Antigen Profile

Antigen Summary

AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003

Alternative names and synonyms associated with AKT1 Substrate 1 (Proline-Rich) (AKT1S1)

  • AKT1 substrate 1 (proline-rich) (akt1s1) Elisa Kit
  • AKT1 substrate 1 (proline-rich) (AKT1S1) Elisa Kit
  • AKT1 substrate 1 (proline-rich) (Akt1s1) Elisa Kit
  • 1110012J22Rik Elisa Kit
  • AI227026 Elisa Kit
  • fb34a04 Elisa Kit
  • Lobe Elisa Kit
  • Lobel Elisa Kit
  • MGC81452 Elisa Kit
  • PRAS40 Elisa Kit
  • wu:fb34a04 Elisa Kit

Protein level used designations for AKT1S1

AKT1 substrate 1 (proline-rich) , proline-rich AKT1 substrate 1 , 40 kDa proline-rich AKT substrate , proline-rich AKT substrate , PKB/Akt substrate 40

431814 Xenopus laevis
456218 Pan troglodytes
496515 Xenopus (Silurana) tropicalis
566559 Danio rerio
84335 Homo sapiens
67605 Mus musculus
292887 Rattus norvegicus
610130 Canis lupus familiaris
514859 Bos taurus
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