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anti-Mouse (Murine) ITPR2 Antibodies:
anti-Rat (Rattus) ITPR2 Antibodies:
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Human Polyclonal ITPR2 Primary Antibody for ELISA, WB - ABIN250904
Ljubojevic, Radulovic, Leitinger, Sedej, Sacherer, Holzer, Winkler, Pritz, Mittler, Schmidt, Sereinigg, Wakula, Zissimopoulos, Bisping, Post, Marsche, Bossuyt, Bers, Kockskämper, Pieske: Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure. in Circulation 2014
Show all 5 Pubmed References
InsP3 dependent sarcoplasmic reticulum-Ca2 (show CA2 Antibodies)+ flux constitute the main mechanism of functional crosstalk between InsP3R2 and RyR2 (show RYR2 Antibodies) resulting in more Ca2 (show CA2 Antibodies)+ sensitized RyRs to trigger subsequent Ca2 (show CA2 Antibodies)+-induced Ca2 (show CA2 Antibodies)+ release activation.
the absence of IP3R2 led to increased innate immunity, which may contribute to the decreased survival of the SOD1(G93A) mice.our data indicate that IP3R2 protects against the negative effects of inflammation, suggesting that the increase in IP3R2 expression in ALS patients is a protective response.
Using inositol 1,4,5-trisphosphate receptor type 2 knockout (Itpr2(-/-)) mice to specifically disturb somatic Ca(2 (show CA2 Antibodies)+) signaling in astrocytes, the authors showed that developmental elimination of the ventral posteromedial nucleus relay synapse was impaired.
IP3R2 KO mice had smaller infarction than WT mice in acute and chronic phases of ischemia
Akt2 (show AKT2 Antibodies) upregulates dendritic cell migration at least in part by ETS1 (show ETS1 Antibodies)-dependent stimulation of IP3R2 transcription.
Disrupting IP3R (show ITPR1 Antibodies)/Bcl-2 (show BCL2 Antibodies) interaction therefore leads in those cells to increased Ca(2 (show CA2 Antibodies)) release and apoptosis. Intriguingly, IP3R2 is not only implicated in apoptosis but also in the induction of senescence, another tumour-suppressive mechanism.
reduced InsP3R (show ITPR1 Antibodies)-II expression is not sufficient to account for any disruptions in metabolic homeostasis that are observed in mouse models of obesity
ITPR2 and hypertrophy specific gene expression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin-NFATc (show NFATC1 Antibodies) signaling pathways.
This study demonistrated that hippocampal slices from inositol triphosphate receptor type 2 (IP3R2) knock-out mice which abolished the astrocytic Ca(2 (show CA2 Antibodies)+) activity.
IP3R (show ITPR1 Antibodies)-deficient acinar cells accumulate zymogen granules, but the mice do not succumb to pancreatic damage or worse pancreatitis outcomes.
Studies indicate that the ryanodine receptors (RyRs: RyR1 (show RYR1 Antibodies), RyR2 (show RYR2 Antibodies), RyR3 (show RYR3 Antibodies)) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1 (show ITPR1 Antibodies), IP3R2, IP3R3 (show ITPR3 Antibodies)) are the major Ca(2 (show CA2 Antibodies)+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR).
Data suggest miR (show MLXIP Antibodies)-1290 as the new oncomiR involved in laryngeal squamous cell carcinoma pathogenesis probably through downregulation of its target genes MAF (show MAF Antibodies) and ITPR2.
results show a functional role of calcium release by the ITPR2 channel and its subsequent accumulation in the mitochondria
High expression of inositol 1,4,5-trisphosphate receptor, type 2 is associated with acute myeloid leukemia (show BCL11A Antibodies).
A genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese.
Loss of InsP3R2-mediated calcium release causes isolated anhidrosis in humans.
The Galphaq (show GNAQ Antibodies)-protein/coupled receptor/IP3R (show ITPR1 Antibodies) axis modulates the electromechanical properties of the human myocardium and its propensity to develop arrhythmias.
Studies indicate that three subtypes of inositol 1,4,5-trisphosphate (IP3) receptors (IP3R1 (show ITPR1 Antibodies), -2, and -3) are assembled to form homo- and heterotetrameric channels that mediate Ca(2 (show CA2 Antibodies)+) release from intracellular stores.
receptor for inositol 1,4,5-triphosphate\; involved in regulating intracellular Ca(2+) concentration
inositol 1,4,5-trisphosphate receptor, type 2
, inositol 1,4,5-triphosphate receptor, type 2
, IP3 receptor
, IP3R 2
, inositol 1,4,5-triphosphate receptor 5
, inositol 1,4,5-trisphosphate receptor type 2
, inositol 1,4,5-trisphosphate type V receptor
, inositol trisphosphate receptor type 2
, type 2 InsP3 receptor
, type 2 inositol 1,4,5-trisphosphate receptor
, inositol 1,4,5-triphosphate receptor 2
, inositol triphosphate receptor type 2