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anti-Human HYAL1 Antibodies:
anti-Mouse (Murine) HYAL1 Antibodies:
anti-Rat (Rattus) HYAL1 Antibodies:
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Human Polyclonal HYAL1 Primary Antibody for IHC, IHC (p) - ABIN4320742
Siiskonen, Poukka, Tyynelä-Korhonen, Sironen, Pasonen-Seppänen: Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma. in BMC cancer 2013
Show all 2 Pubmed References
Human Polyclonal HYAL1 Primary Antibody for ELISA - ABIN314303
Daginakatte, Gutmann: Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth. in Human molecular genetics 2007
Human Polyclonal HYAL1 Primary Antibody for ELISA, WB - ABIN516762
Panogeorgou, Tserbini, Filou, Vynios, Naxakis, Papadas, Goumas, Mastronikolis: Hyaluronan synthases and hyaluronidases in nasal polyps. in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2016
Human Polyclonal HYAL1 Primary Antibody for WB - ABIN516763
Papakonstantinou, Kouri, Karakiulakis, Klagas, Eickelberg: Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension. in The European respiratory journal 2008
HAS2 (show HAS2 Antibodies) and HAS3 (show HAS3 Antibodies) were the only hyaluronan synthases detected, the expression of which was almost similar in NPs (show NPS Antibodies) and NM.
The receiver-operating characteristic curve analyses demonstrated that each one had good sensitivity and specificity for distinguishing BC patients from non-BC ones (HYAL1, miR (show MLXIP Antibodies)-210, miR (show MLXIP Antibodies)-96, lncRNA-UCA1, 91.5 and ).
Study showed that reduced HYAL1 expression was associated with endometrial carcinoma aggressiveness, which further supported the role of hyaluronan degradation in cancer progression.
Results demonstrated that HYAL1 was C-mannosylated and suggest the possible role of C-mannosylation for secretion and enzymatic activity of HYAL1.
Hyaluronan (HA) interacting proteins RHAMM (show HMMR Antibodies) and hyaluronidase (show HAase Antibodies) impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels.
In contrast to the previously described MPS IX patient, our three patients display a phenotype limited to the joints, suggesting that this is the primary manifestation of HYAL1 deficiency.
Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis.
This is the first report showing high HYAL-1 levels in epithelial ovarian cancer.
HYAL-1 and HAS1 (show HAS1 Antibodies) expression predicted BCa (show BLNK Antibodies) metastasis, and HYAL-1 expression also predicted disease-specific survival.
HYAL1 overexpression is correlated with the malignant behavior of breast cancer.
results are consistent with a role for hyaluronan and hyaluronoglucosaminidase 1 and 2 in the development of the microscopic folds of the pig placenta during gestation
the porcine hyaluronidase (show HAase Antibodies) cluster consisting of genes HYAL1, HYAL2 (show HYAL2 Antibodies) and HYAL3 (show HYAL3 Antibodies) was characterized
This study focuses on the investigation of the digestibility of glycosaminoglycans with different degrees of sulfation by bovine testicular hyaluronidase (show HAase Antibodies).
It was concluded that: HYAL1 and HYAL2 (show HYAL2 Antibodies) are both needed for tissue HA catabolism; 2) HYAL2 (show HYAL2 Antibodies) is required for high MW HA clearance in lymph nodes and plasma and for HA endocytosis by liver NPCs; and 3) the main role of HYAL1 is HA degradation within liver NPCs.
Findings suggest that HYAL1 contributes to endothelial and glycocalyx dysfunction induced by diabetes. HYAL1 inhibitors could be explored as a new therapeutic approach to prevent vascular complications in diabetes.
HYAL1 is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 (show HYAL2 Antibodies) is essential for the degradation of extracellular HA in all kidney regions
The activity of the processed form of Hyal-1 was largely underestimated.
The knockdown of Hyal-1 results in an 80% decrease of total acid hyaluronidase (show HAase Antibodies) activity in the mouse liver, confirming that Hyal-1 is a key actor of hyaluronic acid catabolism in this organ.
Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies through HYAL1
both HYAL1 and beta-hexosaminidase (show HEXA Antibodies) cleave chondroitin sulfate, but it is a preferred substrate for beta-hexosaminidase (show HEXA Antibodies). These studies provide in vivo evidence to support and extend existing knowledge of GAG breakdown.
Data show that Hyal-1, but not Hyal-3 (show HYAL3 Antibodies),is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin (show FST Antibodies)/activin (show Actbeta Antibodies)/Smad3 (show SMAD3 Antibodies) pathway.
Endothelial surface layer degradation by chronic hyaluronidase (show HAase Antibodies) infusion induces proteinuria in apolipoprotein E (show APOE Antibodies)-deficient mice
Characterization of the murine hyaluronidase (show HAase Antibodies) gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 (show NAT6 Antibodies) and Hyal3 (show HYAL3 Antibodies).
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
, lung carcinoma protein 1
, plasma hyaluronidase
, tumor suppressor LUCA-1
, hyaluronidase 1