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anti-Mouse (Murine) CISH antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended CISH Antibody (supplied by: Log in to see )

Antigen
Cytokine Inducible SH2-Containing Protein (CISH) Antibodies
  • AI385595
  • BACTS2
  • CIS
  • Cis
  • cis
  • CIS-1
  • cis-1
  • CIS1
  • cish
  • CISH
  • cish.a
  • F17
  • F23
  • g18
  • G18
  • ptk9l
  • SOCS
  • socs
  • twf1l
  • wu:fk57g04
  • zgc:91817
  • zgc:154062
Epitope
AA 241-258
5
5
3
2
2
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
21
8
4
1
Host
Rabbit
22
2
Clonality
Polyclonal
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
22
5
5
5
4
2
1
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Catalog No. ABIN3030694
$ 378.13
Plus shipping costs $45.00

Similar anti-CISH Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine) Human
ELISA 1 Antibodies 1 Antibodies 2 Antibodies
Immunocytochemistry (ICC) 4 Antibodies 1 Antibodies 7 Antibodies
Immunofluorescence (IF) 2 Antibodies 6 Antibodies
Immunohistochemistry (IHC) 2 Antibodies 2 Antibodies 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 4 Antibodies 1 Antibodies 7 Antibodies
Western Blotting (WB) 5 Antibodies 8 Antibodies
Immunochromatography (IC) 1 Antibodies

General

Antigen Cytokine Inducible SH2-Containing Protein (CISH) Antibodies
Epitope AA 241-258
(5), (5), (3), (2), (2), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(21), (8), (4), (1)
Host Rabbit
(22), (2)
Clonality
Polyclonal
Application Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(22), (5), (5), (5), (4), (2), (1)
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Product Details anti-CISH Antibody

Target Details CISH Application Details Handling Images
Purification Antigen affinity purified
Immunogen Amino acids 241-258 (LPLPRRMADYLRQYPFQL) were used as the immunogen for this CISH antibody (100% homologous in human, mouse and rat).
Isotype IgG

Target Details CISH

Product Details anti-CISH Antibody Application Details Handling Images back to top
Antigen
Alternative Name CISH (CISH Antibody Abstract)
Background Cytokine inducible SH2-containing protein, also called CIS, CIS-1, G18, SOCS, is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling (SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria. The human gene is mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on chromosome 9, a region syntenic to human chromosome 3p21. CISH expression was upregulated by lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression of CISH. Gain- and loss-of-function studies showed that CISH accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure.
UniProt Q9NSE2
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Pathways JAK-STAT Signaling

Application Details

Product Details anti-CISH Antibody Target Details CISH Handling Images back to top
Application Notes The stated application concentrations are suggested starting amounts. Titration of the CISH antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL
Restrictions For Research Use only

Handling

Product Details anti-CISH Antibody Target Details CISH Application Details Images back to top
Buffer 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Storage -20 °C
Storage Comment After reconstitution, the CISH antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.