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|Antigen||Interferon, beta 1, Fibroblast (IFNB1) Antibodies|
|Conjugate||This IFNB1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|2 references available|
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Product Details anti-IFNB1 AntibodyTarget Details IFNB1 Application Details Handling References for anti-IFNB1 antibody (ABIN453696) Images
|Specificity||This antibody reacts to IFNB1.|
|Purification||Affinity chromatography on Protein A|
|Immunogen||KLH conjugated synthetic peptide selected from the N-terminal region of human Interferon beta 1/IFNB1.|
Target Details IFNB1Product Details anti-IFNB1 Antibody Application Details Handling References for anti-IFNB1 antibody (ABIN453696) Images back to top
|Alternative Name||IFNB / Interferon beta (IFNB1 Antibody Abstract)|
|Background||The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers. They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity. The human IFN alphas are encoded by a family of at least 15 different genes, while IFN beta is the unique member of its subtype. There is approximately 50 % amino acid homology between the alpha and beta subtypes. Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities. Differences between alpha subtypes, and between IFN alpha and betas, are in potency and cell type specific activities. In particular, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2. IFNB1 has antiviral, antibacterial and anticancer activities.Synonyms: Fibroblast interferon, IFB, IFN-beta, IFNB1|
|Pathways||JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy|
Application DetailsProduct Details anti-IFNB1 Antibody Target Details IFNB1 Handling References for anti-IFNB1 antibody (ABIN453696) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IFNB1 Antibody Target Details IFNB1 Application Details References for anti-IFNB1 antibody (ABIN453696) Images back to top
|Buffer||PBS containing 0.09 % (W/V) sodium azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-IFNB1 antibody (ABIN453696)Product Details anti-IFNB1 Antibody Target Details IFNB1 Application Details Handling Images back to top
Lienenklaus, Cornitescu, Zietara, Łyszkiewicz, Gekara, Jabłónska, Edenhofer, Rajewsky, Bruder, Hafner, Staeheli, Weiss: "Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 5, pp. 3229-36, 2009
Eto, Takahashi: "Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon." in: Nature medicine, Vol. 5, Issue 5, pp. 577-81, 1999
ImagesProduct Details anti-IFNB1 Antibody Target Details IFNB1 Application Details Handling References for anti-IFNB1 antibody (ABIN453696) back to top